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OTX015

Known as: 6H-Thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine-6-acetamide, 4-(4-Chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-, (6S)-, BRD 2/3/4 Inhibitor OTX015 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

AcetanilidesHeterocyclic Compounds, 3-Ring
BET Bromodomains 2/3/4 Inhibitor MK-8628

Papers overview

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2017
2017
Mitochondrial matrix chaperone and c-myc inhibition causes enhanced lethality in glioblastoma
Malignant gliomas display high levels of the transcription factor c-myc and organize a tumor specific chaperone network within… 
2016
2016
Dose optimization of MK-8628 (OTX015), a small molecule inhibitor of bromodomain and extra-terminal (BET) proteins, in patients (pts) with recurrent glioblastoma (GB).
e14123Background: Bromodomains (BRD) bind to acetylated lysine residues on histone tails and are directly involved in remodeling… 
2016
2016
Methaphylactic effect of tulathromycin treatment on rumen fluid parameters in feedlot beef cattle.
The aim of this study was to evaluate the effect of tulathromycin as a bovine respiratory disease (BRD) metaphylactic treatment… 
2015
2015
Abstract 2625: Targeting prostate cancer stem cells (CSCs) with the novel BET bromodomain (BRD) protein inhibitor OTX015
In human neoplasias small subpopulations of cancer cells with stem cell-like properties are thought to play a role in progression… 
2013
2013
Preclinical Study Of The Bromodomain Inhibitor OTX015 In Acute Myeloid (AML) and Lymphoid (ALL) Leukemias
Background Bromodomain and extra-terminal (BET) proteins, including the ubiquitous BRD2/3/4 proteins, are epigenetic readers… 
2012
2012
The Brd-Inhibitor OTX015 Shows Pre-Clinical Activity in Anaplastic Large T-Cell Lymphoma (ALCL)
Abstract 4872 Background: ALCL, is clinically/biologically heterogeneous disease, including ALK+ and ALK- systemic forms. Despite… 
2012
2012
The Brd-Inhibitor OTX015 Is Active in Pre-Clinical Models of Mature B-Cell Lymphoid Tumors
Abstract 1657 Background: Bromodomain-containing proteins play an important role in gene expression regulation, via chromatin… 
2011
2011
[Studies on chemical constitutes from callus cultures of Stellera chamaejasme].
From callus cultures of Stellera chamaejasme, 17 compounds were isolated. Based on their physical and chemical data and… 
2005
2005
Developmental Indices of Nutritionally Induced Placental Growth Restriction in the Adolescent Sheep
Most intrauterine growth restriction cases are associated with reduced placental growth. Overfeeding adolescent ewes undergoing… 
Review
1995
Review
1995
EVIDENCE FOR THE USE OF PHONOLOGICAL REPRESENTATIONS DURING TRANSSACCADIC WORD RECOGNITION
The authors explored the role of phonological representations in the integration of lexical information across saccadic eye… 
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