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OTUB1 gene

Known as: OTU1, OTUBAIN 1, OTU deubiquitinase, ubiquitin aldehyde binding 1 
 
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
BackgroundOTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1) is a deubiquitinating enzyme (DUB) that belongs to the OTU… Expand
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Highly Cited
2013
Highly Cited
2013
SMAD transcription factors are key intracellular transducers of TGFβ cytokines. SMADs are tightly regulated to ensure balanced… Expand
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Highly Cited
2013
Highly Cited
2013
The cellular inhibitor of apoptosis (c‐IAP) proteins are E3 ubiquitin ligases that are critical regulators of tumour necrosis… Expand
Highly Cited
2012
Highly Cited
2012
Ubiquitylation entails the concerted action of E1, E2, and E3 enzymes. We recently reported that OTUB1, a deubiquitylase… Expand
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Highly Cited
2012
Highly Cited
2012
The ubiquitin (Ub)–proteasome system plays a pivotal role in the regulation of p53 protein stability and activity. p53 is… Expand
Highly Cited
2012
Highly Cited
2012
Histones are ubiquitinated in response to DNA double-strand breaks (DSB), promoting recruitment of repair proteins to chromatin… Expand
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Highly Cited
2010
Highly Cited
2010
DNA double-strand breaks (DSBs) pose a potent threat to genome integrity. These lesions also contribute to the efficacy of… Expand
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Highly Cited
2009
Highly Cited
2009
Ubiquitination and deubiquitination have emerged as critical post-translational regulatory mechanisms for activation or… Expand
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Highly Cited
2008
Highly Cited
2008
Ubiquitination of proteins modifies protein function by either altering their activities, promoting their degradation, or… Expand
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Highly Cited
1993
Highly Cited
1993
In addition to controlling somatic sexual development in Drosophila melanogaster, the Sex-lethal (Sxl) gene is required for… Expand
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