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OTUB1 gene

Known as: OTU1, OTUBAIN 1, OTU deubiquitinase, ubiquitin aldehyde binding 1 
National Institutes of Health

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2 relations

Broader (1)

Genes
OTUD1 gene

Papers overview

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2020
2020
Comparison of cross-regulation by different OTUB1-E2 complexes.
OTUB1 is a highly expressed cysteine protease that specifically cleaves K48-linked polyubiquitin chains. This unique… 
2019
2019
Deubiquitinase Otub1 negatively regulates IL-15 signaling in CD8 T cells and NK cells
Regulation of cells with cytotoxic functionality is crucial to provide an effective and proportional response to immune… 
2017
2017
Effects of an Addition of Different Essential Oils and Their Combinations to Diets on Performance and Carcass Characteristics Parameters in Broilers
This study was conducted to determine the effect of dietary supplementation of thymus (Thymus vulgaris L.), rosemary (Rosmarinus… 
2015
2015
Proteomic Profiling of SupT1 Cells Reveal Modulation of Host Proteins by HIV-1 Nef Variants
Nef is an accessory viral protein that promotes HIV-1 replication, facilitating alterations in cellular pathways via multiple… 
2014
2014
Crystallization and preliminary X-ray crystallographic analysis of the complex between the N-D1 domain of VCP from Homo sapiens and the N domain of OTU1 from Saccharomyces cerevisiae.
VCP (valosin-containing protein; also known as p97) plays important roles in many biological processes including the ERAD… 
2012
2012
OTUB1 Overexpression in Mesangial Cells Is a Novel Regulator in the Pathogenesis of Glomerulonephritis through the Decrease of DCN Level
Background OTUB1 is a member of OTUs (Ovarian-tumor-domain-containing proteases), a deubiquitinating enzymes family (DUBs), which… 
2012
2012
Analysis of binary interactions between OTUB1 and E2 ubiquitin-conjugating enzymes
Post-translational modification of proteins via ubiquitination is mediated by three enzyme families; E1 activating enzymes, E2… 
2011
2011
When cleavage is not attractive: non-catalytic inhibition of ubiquitin chains at DNA double-strand breaks by OTUB1.
2009
2009
Partial molecular cloning, characterization, and analysis of the subcellular localization and expression patterns of the porcine OTUB1 gene
The product of the OTUB1 gene is a member of the OTU superfamily of predicted cysteine proteases and inhibits cytokine gene… 
Highly Cited
2008
Highly Cited
2008
Structural Basis for Ubiquitin Recognition by the Otu1 Ovarian Tumor Domain Protein*
Ubiquitination of proteins modifies protein function by either altering their activities, promoting their degradation, or… 
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