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OTUB1 gene

Known as: OTU1, OTUBAIN 1, OTU deubiquitinase, ubiquitin aldehyde binding 1 
 
National Institutes of Health

Papers overview

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2016
2016
Activation of the RAS oncogenic pathway, frequently ensuing from mutations in RAS genes, is a common event in human cancer… Expand
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2014
2014
BackgroundOTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1) is a deubiquitinating enzyme (DUB) that belongs to the OTU… Expand
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Highly Cited
2013
Highly Cited
2013
SMAD transcription factors are key intracellular transducers of TGFβ cytokines. SMADs are tightly regulated to ensure balanced… Expand
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2013
2013
The cellular inhibitor of apoptosis (c-IAP) proteins are E3 ubiquitin ligases that are critical regulators of tumour necrosis… Expand
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2013
2013
OTUB1 is a Lys48-specific deubiquitinating enzyme that forms a complex in vivo with E2 ubiquitin (Ub)-conjugating enzymes… Expand
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Highly Cited
2012
Highly Cited
2012
Histones are ubiquitinated in response to DNA double-strand breaks (DSB), promoting recruitment of repair proteins to chromatin… Expand
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Highly Cited
2012
Highly Cited
2012
Ubiquitylation entails the concerted action of E1, E2, and E3 enzymes. We recently reported that OTUB1, a deubiquitylase… Expand
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Highly Cited
2010
Highly Cited
2010
DNA double-strand breaks (DSBs) pose a potent threat to genome integrity. These lesions also contribute to the efficacy of… Expand
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Highly Cited
2010
Highly Cited
2010
Ubiquitination and deubiquitination have emerged as critical post-translational regulatory mechanisms for activation or… Expand
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Highly Cited
2008
Highly Cited
2008
Ubiquitination of proteins modifies protein function by either altering their activities, promoting their degradation, or… Expand
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