ORF74 protein, Human herpesvirus 8

Known as: ORF-74 protein, HHV-8, Protein ORF74, Putative G-Protein Coupled Receptor 
Viral G-protein coupled receptor (342 aa, ~39 kDa) is encoded by the human herpesvirus 8 ORF74 gene. This protein plays a role in the positive… (More)
National Institutes of Health

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8 relations
Genes, ViralHHV8 ORF74 GenePositive Regulation of AngiogenesisSignal Transduction
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Broader (2)

Viral Proteinschemokine receptor

Papers overview

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2009
2009
Role of ORF74-encoded viral G protein-coupled receptor in human herpesvirus 8 lytic replication.
The human herpesvirus 8 (HHV-8) viral G protein-coupled receptor (vGPCR) has been implicated in virus-associated disease… (More)
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Highly Cited
2006
Highly Cited
2006
The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor.
The Kaposi's sarcoma-associated herpesvirus (KSHV), the infectious causative agent of Kaposi's sarcoma (KS), encodes a G protein… (More)
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2006
2006
The human herpesvirus 8 chemokine receptor vGPCR triggers autonomous proliferation of endothelial cells.
We have used a novel conditional transgenic system to study the mechanisms of angioproliferation induced by viral G protein… (More)
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Highly Cited
2005
Highly Cited
2005
Inhibition of phosphatidylinositol 3'-kinase/AKT signaling promotes apoptosis of primary effusion lymphoma cells.
PURPOSE Phosphatidylinositol 3'-kinase (PI3'-kinase) can be activated by the K1 protein of Kaposi sarcoma-associated herpes virus… (More)
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2005
2005
The targeting of primary effusion lymphoma cells for apoptosis by inducing lytic replication of human herpesvirus 8 while blocking virus production.
Primary effusion lymphoma (PEL) is a B-cell lymphoma in which human herpesvirus-8 (HHV-8) is found within all tumor cells and… (More)
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2004
2004
Tumorigenesis by human herpesvirus 8 vGPCR is accelerated by human immunodeficiency virus type 1 Tat.
Human herpesvirus 8 (HHV-8), also called Kaposi's sarcoma (KS) herpesvirus, can cause KS but is inefficient. Untreated human… (More)
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Highly Cited
2004
Highly Cited
2004
Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor.
We have recently engineered an in vivo endothelial cell-specific retroviral gene transfer system and found that a single Kaposi's… (More)
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Highly Cited
2003
Highly Cited
2003
Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/ KDR.
The G protein-coupled receptor oncogene (vGPCR) of the Kaposi's sarcoma (KS) associated herpesvirus (KSHV), an oncovirus… (More)
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1998
1998
Human Interferon-γ–inducible Protein 10 (IP-10) Inhibits Constitutive Signaling of Kaposi's Sarcoma–associated Herpesvirus G Protein–coupled Receptor
A G protein-coupled receptor (GPCR) is encoded within the genome of Kaposi's sarcoma- associated herpesvirus (KSHV)/human… (More)
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Highly Cited
1990
Highly Cited
1990
Human cytomegalovirus encodes three G protein-coupled receptor homologues
HUMAN cytomegalovirus (HCMV) is a herpesvirus with a genome of 230 kilobases (Kb) encoding about 200 genes1. Although infection… (More)
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