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ORF74 protein, Human herpesvirus 8

Known as: ORF-74 protein, HHV-8, Protein ORF74, Putative G-Protein Coupled Receptor 
Viral G-protein coupled receptor (342 aa, ~39 kDa) is encoded by the human herpesvirus 8 ORF74 gene. This protein plays a role in the positive… 
National Institutes of Health

Related topics

Related topics

9 relations
Cell Migration InductionGenes, ViralHHV8 ORF74 GenePositive Regulation of Angiogenesis

Broader (2)

Viral Proteinschemokine receptor

Papers overview

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2015
2015
Glycosylation of KSHV Encoded vGPCR Functions in Its Signaling and Tumorigenicity
Kaposi’s sarcoma-associated herpesvirus (KSHV) is a tumor virus and the etiologic agent of Kaposi’s Sarcoma (KS). KSHV G protein… 
Review
2014
Review
2014
Molecular biology of human herpesvirus 8: novel functions and virus-host interactions implicated in viral pathogenesis and replication.
Human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV), is the second identified human… 
2012
2012
Lymphatic reprogramming by Kaposi sarcoma herpes virus promotes the oncogenic activity of the virus-encoded G-protein-coupled receptor.
Kaposi sarcoma, the most common cancer in HIV-positive individuals, is caused by endothelial transformation mediated by the… 
2012
2012
Kaposi's Sarcoma-Associated Herpesvirus G-Protein-Coupled Receptor Prevents AU-Rich-Element-Mediated mRNA Decay
ABSTRACT During lytic Kaposi's sarcoma-associated herpesvirus (KSHV) infection, host gene expression is severely restricted by a… 
2009
2009
Kaposi's sarcoma virally encoded, G-protein-coupled receptor: a paradigm for paracrine transformation.
Highly Cited
2008
Highly Cited
2008
Dual inhibition of PI3Kalpha and mTOR as an alternative treatment for Kaposi's sarcoma.
Rapamycin (or sirolimus), the prototypical inhibitor of the mammalian target of rapamycin (mTOR) and an immunosuppressant used… 
2008
2008
Kaposi's Sarcoma-Associated Herpesvirus K7 Induces Viral G Protein-Coupled Receptor Degradation and Reduces Its Tumorigenicity
The Kaposi's sarcoma-associated herpesvirus (KSHV) genome encodes a G protein-coupled receptor (vGPCR). vGPCR is a ligand… 
2006
2006
KSHV G protein-coupled receptor inhibits lytic gene transcription in primary-effusion lymphoma cells via p21-mediated inhibition of Cdk2.
Kaposi sarcoma (KS) remains the most common AIDS-associated malignancy worldwide. In sub-Saharan Africa especially, this… 
Review
2006
Review
2006
Emerging targets and novel strategies in the treatment of AIDS‐related Kaposi's sarcoma: Bidirectional translational science
Through the mentorship process, Dr. Arthur Pardee emphasized the critical importance of bidirectional translational research—not… 
2005
2005
Splicing of Rhesus Rhadinovirus R15 and ORF74 Bicistronic Transcripts during Lytic Infection and Analysis of Effects on Production of vCD200 and vGPCR
ABSTRACT Rhesus macaque rhadinovirus (RRV) is the rhesus macaque homologue of human herpesvirus 8 (HHV-8). Here we examine… 
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