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ORF74 protein, Human herpesvirus 8
Known as:
ORF-74 protein, HHV-8
, Protein ORF74
, Putative G-Protein Coupled Receptor
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Viral G-protein coupled receptor (342 aa, ~39 kDa) is encoded by the human herpesvirus 8 ORF74 gene. This protein plays a role in the positive…
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National Institutes of Health
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Related topics
Related topics
9 relations
Cell Migration Induction
Genes, Viral
HHV8 ORF74 Gene
Positive Regulation of Angiogenesis
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Broader (2)
Viral Proteins
chemokine receptor
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Glycosylation of KSHV Encoded vGPCR Functions in Its Signaling and Tumorigenicity
Hui-na Wu
,
Liqun Liu
,
Jun Xiao
,
Mengdie Chi
,
Yixiao Qu
,
Hao Feng
Viruses
2015
Corpus ID: 235727
Kaposi’s sarcoma-associated herpesvirus (KSHV) is a tumor virus and the etiologic agent of Kaposi’s Sarcoma (KS). KSHV G protein…
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Review
2014
Review
2014
Molecular biology of human herpesvirus 8: novel functions and virus-host interactions implicated in viral pathogenesis and replication.
E. Cousins
,
J. Nicholas
Recent results in cancer research. Fortschritte…
2014
Corpus ID: 45250289
Human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV), is the second identified human…
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2012
2012
Lymphatic reprogramming by Kaposi sarcoma herpes virus promotes the oncogenic activity of the virus-encoded G-protein-coupled receptor.
B. Aguilar
,
Inho Choi
,
+13 authors
Young-Kwon Hong
Cancer Research
2012
Corpus ID: 19679004
Kaposi sarcoma, the most common cancer in HIV-positive individuals, is caused by endothelial transformation mediated by the…
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2012
2012
Kaposi's Sarcoma-Associated Herpesvirus G-Protein-Coupled Receptor Prevents AU-Rich-Element-Mediated mRNA Decay
Jennifer A. Corcoran
,
Denys A. Khaperskyy
,
+4 authors
C. McCormick
Journal of Virology
2012
Corpus ID: 35808671
ABSTRACT During lytic Kaposi's sarcoma-associated herpesvirus (KSHV) infection, host gene expression is severely restricted by a…
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2009
2009
Kaposi's sarcoma virally encoded, G-protein-coupled receptor: a paradigm for paracrine transformation.
Daniel Martin
,
J. Gutkind
Methods in Enzymology
2009
Corpus ID: 22902212
Highly Cited
2008
Highly Cited
2008
Dual inhibition of PI3Kalpha and mTOR as an alternative treatment for Kaposi's sarcoma.
R. Chaisuparat
,
Jiadi Hu
,
B. Jham
,
Z. Knight
,
K. Shokat
,
S. Montaner
Cancer Research
2008
Corpus ID: 44772847
Rapamycin (or sirolimus), the prototypical inhibitor of the mammalian target of rapamycin (mTOR) and an immunosuppressant used…
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2008
2008
Kaposi's Sarcoma-Associated Herpesvirus K7 Induces Viral G Protein-Coupled Receptor Degradation and Reduces Its Tumorigenicity
Hao Feng
,
Xiaonan Dong
,
Ashley Negaard
,
P. Feng
PLoS Pathogens
2008
Corpus ID: 1201330
The Kaposi's sarcoma-associated herpesvirus (KSHV) genome encodes a G protein-coupled receptor (vGPCR). vGPCR is a ligand…
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2006
2006
KSHV G protein-coupled receptor inhibits lytic gene transcription in primary-effusion lymphoma cells via p21-mediated inhibition of Cdk2.
M. Cannon
,
E. Cesarman
,
C. Boshoff
Blood
2006
Corpus ID: 206863076
Kaposi sarcoma (KS) remains the most common AIDS-associated malignancy worldwide. In sub-Saharan Africa especially, this…
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Review
2006
Review
2006
Emerging targets and novel strategies in the treatment of AIDS‐related Kaposi's sarcoma: Bidirectional translational science
B. Dezube
,
R. Sullivan
,
H. Koon
Journal of Cellular Physiology
2006
Corpus ID: 36886982
Through the mentorship process, Dr. Arthur Pardee emphasized the critical importance of bidirectional translational research—not…
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2005
2005
Splicing of Rhesus Rhadinovirus R15 and ORF74 Bicistronic Transcripts during Lytic Infection and Analysis of Effects on Production of vCD200 and vGPCR
Carly L Pratt
,
Ryan D Estep
,
S. Wong
Journal of Virology
2005
Corpus ID: 22075715
ABSTRACT Rhesus macaque rhadinovirus (RRV) is the rhesus macaque homologue of human herpesvirus 8 (HHV-8). Here we examine…
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