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ORAI1 Protein

Known as: Calcium Release Activated Calcium Channel Protein 1, Calcium Release-Activated Calcium Channel Protein 1, ORAI Calcium Release-Activated Calcium Modulator 1 
The pore-forming subunit of calcium release activated calcium channels. It is activated by STROMAL INTERACTION MOLECULE 1 upon intracellular calcium… Expand
National Institutes of Health

Papers overview

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2018
2018
In the present study, we have applied ratiometric measurements of intracellular Ca2+ concentrations ([Ca2+]i) to show that… Expand
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Review
2017
Review
2017
Ca2+ influx by plasma membrane Ca2+ channels is the crucial component of the receptor-evoked Ca2+ signal. The two main Ca2… Expand
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Highly Cited
2016
Highly Cited
2016
Orai channels mediate store-operated Ca2+ signals crucial in regulating transcription in many cell types, and implicated in… Expand
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2015
2015
Store-operated CRAC channels regulate a wide range of cellular functions including gene expression, chemotaxis, and proliferation… Expand
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2015
2015
Significance Calcium ions serve as intracellular signals controlling many aspects of cell behavior. Here, we create fusions of… Expand
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2015
2015
Significance Close appositions between the endoplasmic reticulum (ER) and the plasma membrane in mammalian cells have essential… Expand
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Highly Cited
2014
Highly Cited
2014
STIM1 and Orai1 move to endoplasmic reticulum–plasma membrane (ER-PM) junctions to trigger store-operated Ca2+ entry. Single… Expand
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2013
2013
Purinergic receptor expression and involvement in steroidogenesis were examined in NCI-H295R (H295R), a human adrenal cortex cell… Expand
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Review
2011
Review
2011
In most cases, metastasis, not the primary tumour per se, is the main cause of mortality in cancer patients. In order to… Expand
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Highly Cited
2009
Highly Cited
2009
STIM proteins are sensors of endoplasmic reticulum (ER) luminal Ca2+ changes and rapidly translocate into near plasma membrane… Expand
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