ORAI1 Protein

Known as: Calcium Release Activated Calcium Channel Protein 1, Calcium Release-Activated Calcium Channel Protein 1, ORAI Calcium Release-Activated Calcium Modulator 1 
The pore-forming subunit of calcium release activated calcium channels. It is activated by STROMAL INTERACTION MOLECULE 1 upon intracellular calcium… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2009-2017
0246820092017

Papers overview

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2017
2017
Sodium butyrate (NaBu), a histone deacetylase inhibitor, has demonstrated anti-tumor effects in several cancers, and is a… (More)
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2016
2016
Orai channels mediate store-operated Ca2+ signals crucial in regulating transcription in many cell types, and implicated in… (More)
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2016
2016
Orai1 comprises the pore-forming subunit of the Ca(2+) release-activated Ca(2+) (CRAC) channel. When bound and activated by… (More)
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2015
2015
Accumulation of extracellular matrix derived from glomerular mesangial cells is an early feature of diabetic nephropathy. Ca(2… (More)
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2015
2015
The stromal interaction molecule (STIM)-ORAI calcium release-activated calcium modulator (ORAI) pathway controls store-dependent… (More)
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Review
2015
Review
2015
The regulatory protein STIM1 controls gating of the Ca(2+) channel ORAI1 by a direct protein-protein interaction. Because STIM1… (More)
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2014
2014
Following endoplasmic reticulum (ER) Ca(2+) depletion, STIM1 and Orai1 complexes assemble autonomously at ER-plasma membrane (PM… (More)
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2013
2013
Orai1 calcium channels in the plasma membrane are activated by stromal interaction molecule-1 (STIM1), an endoplasmic reticulum… (More)
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2011
2011
The endoplasmic reticulum Ca(2+)-sensing STIM proteins mediate Ca(2+) entry signals by coupling to activate plasma membrane Orai… (More)
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2009
2009
STIM proteins are sensors of endoplasmic reticulum (ER) luminal Ca(2+) changes and rapidly translocate into near plasma membrane… (More)
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