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OPCML protein, human

Known as: OPCML, cell adhesion molecule-like protein, human, Opioid-Binding Protein/Cell Adhesion Molecule 
Opioid-binding protein/cell adhesion molecule (345 aa, ~38 kDa) is encoded by the human OPCML gene. This protein may be involved in opioid signaling.
National Institutes of Health

Related topics

Related topics

12 relations

Broader (2)

Cell Adhesion MoleculesGPI-Linked Proteins
Cell-Cell Adhesion ProcessImmunoglobulin C2-set DomainImmunoglobulin Family ProteinLigand Binding

Papers overview

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2015
2015
OPCML is frequently methylated in human colorectal cancer and its restored expression reverses EMT via downregulation of smad signaling.
Emerging evidence has indicated that the expression of OPCML gene is frequently altered in a variety of cancers. We previously… 
Highly Cited
2012
Highly Cited
2012
Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector
The Ras association and PH domains of RIAM function as a proximity detector for activated Rap1 and PI(4,5)P2. 
2012
2012
The OPCML tumor suppressor functions as a cell surface repressor-adaptor, negatively regulating receptor tyrosine kinases in epithelial ovarian cancer.
UNLABELLED Epithelial ovarian cancer is the leading cause of death from gynecologic malignancy, and its molecular basis is poorly… 
Highly Cited
2009
Highly Cited
2009
IgLON cell adhesion molecules regulate synaptogenesis in hippocampal neurons
IgLON cell adhesion molecules (CAMs) belonging to the immunoglobulin superfamily comprise of LAMP, neurotrimin (Ntm), OBCAM, and… 
Highly Cited
2003
Highly Cited
2003
Biochemical and ultrastructural analyses of iglon cell adhesion molecules, kilon and obcam in the rat brain
Highly Cited
2002
Highly Cited
2002
Complementary expression and heterophilic interactions between IgLON family members neurotrimin and LAMP.
Neurotrimin (Ntm) and the limbic system-associated membrane protein (LAMP) are members of the IgLON (LAMP, OBCAM, Ntm) family of… 
Highly Cited
2000
Highly Cited
2000
Co-localisation, heterophilic interactions and regulated expression of IgLON family proteins in the chick nervous system.
1996
1996
CEPU-1, a novel immunoglobulin superfamily molecule, is expressed by developing cerebellar Purkinje cells
Proteins of the immunoglobulin superfamily (IgSF) are involved in a variety of specific cell-cell interactions in the developing… 
1996
1996
A family of glycoproteins (GP55), which inhibit neurite outgrowth, are members of the Ig superfamily and are related to OBCAM, neurotrimin, LAMP and CEPU-1.
We have previously identified a glycosylphosphatidylinositol-linked glycoprotein of 55 kDa (GP55) which inhibits neurite… 
Review
1990
Review
1990
Molecular characterization of opioid receptors.
Though opioid receptors are more difficult to purify and characterize than other cell surface receptors, significant progress has… 
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