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OPC-14523

Known as: PRS-013 
National Institutes of Health

Papers overview

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2007
2007
Effects of OPC-14523, a combined sigma and 5-HT1a ligand, on pre- and post-synaptic 5-HT1a receptors
OPC-14523 (OPC) is a novel compound with high affinity for sigma and 5-HT1A receptors that shows ‘antidepressant-like’ effects in… 
2005
2005
In vitro profile of the antidepressant candidate OPC-14523 at rat and human 5-HT1A receptors.
2004
2004
Effects of the Potential Antidepressant OPC-14523 [1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone Monomethanesulfonate] a Combined σ and 5-HT1A Ligand: Modulation…
OPC-14523 (OPC; [1-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone monomethanesulfonate)] is a… 
2004
2004
Ligand : Modulation of Neuronal Activity in the Dorsal Raphe Nucleus
  • 2004
  • Corpus ID: 43134784
OPC-14523 (OPC; [1-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone monomethanesulfonate)] is a… 
2002
2002
Attenuation of scopolamine-induced and age-associated memory impairments by the sigma and 5-hydroxytryptamine(1A) receptor agonist OPC-14523 (1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy…
Sigma and 5-HT(1A) receptor stimulation can increase acetylcholine (ACh) release in the brain. Because ACh release facilitates… 
2002
2002
Attenuation of Scopolamine-Induced and Age-Associated Memory Impairments by the Sigma and 5-Hydroxytryptamine 1 A Receptor Agonist OPC-14523 ( 1-{ 3-[ 4-( 3-chlorophenyl )
Sigma and 5-HT1A receptor stimulation can increase acetylcholine (ACh) release in the brain. Because ACh release facilitates… 
Highly Cited
2001
Highly Cited
2001
Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523
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