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Pseudomonas aeruginosa is a common cause for healthcare-associated infections, which have been historically treated by… Expand ABSTRACT The development of effective inhibitors that block extended-spectrum β-lactamases (ESBLs) and restore the action of… Expand ABSTRACT OP0595 (RG6080) is a novel diazabicyclooctane that inhibits class A and C serine beta-lactamases. Although the… Expand OBJECTIVES
The diazabicyclooctane β-lactamase inhibitor OP0595 (RG6080) also acts as an antibiotic, targeting PBP2 in… Expand ABSTRACT Gram-negative bacteria are evolving to produce β-lactamases of increasing diversity that challenge antimicrobial… Expand OBJECTIVES
The production of a growing diversity of β-lactamases by Gram-negative bacteria challenges antimicrobial chemotherapy… Expand BACKGROUND
OP0595 is a diazabicyclooctane that (i) acts as a PBP2-active antibacterial, (ii) inhibits Class A and C β-lactamases… Expand ABSTRACT OP0595 is a novel diazabicyclooctane which, like avibactam, inhibits class A and C β-lactamases. In addition, unlike… Expand