ONO4819

Prostaglandin E(2) (PGE(2)) positively regulates bone resorption and formation mainly mediated through the EP(4) receptor, a… (More)

To the Editor: Prostanoids constitute a group of cyclooxygenase (COX)-derived metabolites of arachidonic acid, and include… (More)

Bone morphogenetic proteins (BMPs) were originally isolated based on their ability to induce ectopic cartilage and bone formation… (More)

The effects of a prostaglandin EP4 agonist, ONO-4819, and risedronate, a representative anti-resorptive drug, on trabecular… (More)

The influence of a selective agonist for prostaglandin E receptor subtype EP4 (ONO-4819) on the bone response to mechanical… (More)

The reduced stability of hydroxyapatite (HA)-coated implants in osteopenic conditions is considered to be a major problem. We… (More)

The role of prostaglandins in mechanical scratching-induced cutaneous barrier disruption in mice was investigated. Skin… (More)

The anabolic effects of prostaglandin E(2) on bone are effected through the activation of EP4, a G protein-coupled receptor. In… (More)

Indomethacin exerts a strong tocolytic effect by suppressing uterine contractions mediated by prostaglandins. However… (More)

We evaluated the efficacy of ONO-4819, a newly developed agonist of a prostaglandin receptor subtype (EP4), on experimental model… (More)