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ONO-RS 347

Known as: ONO-RS-347 
National Institutes of Health

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Dioxanes

Papers overview

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2013
2013
The pharmacological effects of novokinin; a designed peptide agonist of the angiotensin AT2 receptor.
Novokinin (RPLKPW) was designed based on ovokinin (FRADHPFL), a vasorelaxing peptide derived from ovalbumin. Novokinin relaxed a… 
2011
2011
Interaction of eosinophils with endothelial cells is modulated by prostaglandin EP4 receptors
Eosinophil extravasation across the endothelium is a key feature of allergic inflammation. Here, we investigated the role of PGE2… 
2009
2009
Orally administered novokinin, an angiotensin AT2 receptor agonist, suppresses food intake via prostaglandin E2-dependent mechanism in mice
2007
2007
Prostaglandin E2 downregulates TNF‐α‐induced production of matrix metalloproteinase‐1 in HCS‐2/8 chondrocytes by inhibiting Raf‐1/MEK/ERK cascade through EP4 prostanoid receptor activation
Matrix metalloproteinase‐1 (MMP‐1, collagenase‐1) plays a pivotal role in the process of joint destruction in degenerative joint… 
Highly Cited
2006
Highly Cited
2006
Activation of prostaglandin E receptor EP4 subtype suppresses food intake in mice.
Highly Cited
2005
Highly Cited
2005
Dominant role of prostaglandin E2 EP4 receptor in furosemide-induced salt-losing tubulopathy: a model for hyperprostaglandin E syndrome/antenatal Bartter syndrome.
Increased formation of prostaglandin E2 (PGE2) is a key part of hyperprostaglandin E syndrome/antenatal Bartter syndrome (HPS/aBS… 
2005
2005
Prostaglandin E2 receptor selective agonists E-prostanoid 2 and E-prostanoid 4 may have therapeutic effects on ovalbumin-induced bronchoconstriction.
BACKGROUND The pharmacologic actions of prostaglandin E(2) (PGE(2)) are mediated through specific E-prostanoid (EP)-1, EP-2, EP-3… 
2003
2003
Prostaglandin E receptors in bile ducts of hepatolithiasis patients and the pathobiological significance for cholangitis.
2002
2002
Prostaglandin E(2) inhibits IL-18-induced ICAM-1 and B7.2 expression through EP2/EP4 receptors in human peripheral blood mononuclear cells.
Costimulatory molecules play important roles in immune responses. In the present study we investigated the effects of PGE(2) on… 
2001
2001
Downregulation of Lipopolysaccharide-Induced Intercellular Adhesion Molecule-1 Expression via EP2/EP4 Receptors by Prostaglandin E2 in Human Fibroblasts
In the present study, the effect of prostaglandin E2 (PGE2) on intercellular adhesion molecule-1 (ICAM-1) expression in human… 
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