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ONO-4059

Known as: BTK Inhibitor ONO-4059, Bruton's Tyrosine Kinase Inhibitor ONO-4059 
An orally available formulation containing an inhibitor of Bruton agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity… Expand
National Institutes of Health

Papers overview

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2017
2017
Burton’s Tyrosine Kinase (BTK) plays an important role in B cell signaling, cell proliferation and survival. Hence, it is an… Expand
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2014
2014
Introduction Bruton’s tyrosine kinase (BTK) is a critical kinase involved in B-cell receptor signal transduction. ONO-4059, a… Expand
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2014
2014
2014
Drug developers are mounting a poly(ADPribose) polymerase (PARP) inhibitor comeback, and a few are now experimenting with a more… Expand
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2014
2014
8553 Background: Bruton’s tyrosine kinase (BTK) is a critical kinase involved in B-cell receptor signal transduction. ONO-4059, a… Expand
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2013
2013
Introduction The B-cell receptor (BCR) pathway plays a central role in signal transduction pathways that regulate survival… Expand
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2013
2013
Purpose: The B-cell receptor (BCR) pathway plays a central role in signal transduction pathways that regulate survival… Expand
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2013
2013
Purpose Bruton’s tyrosine kinase (Btk) is a key regulator of the B-cell receptor (BCR) signaling pathway and abberant BCR… Expand
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2013
2013
Introduction The B-cell receptor (BCR) pathway plays a central role in signal transduction pathways that regulate survival… Expand
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2013
2013
Purpose The activated B-cell-like (ABC) sub-type of diffuse large B-cell lymphoma (DLBCL) correlates with poor prognosis. There… Expand
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