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ONO-4059
Known as:
BTK Inhibitor ONO-4059
, Bruton's Tyrosine Kinase Inhibitor ONO-4059
An orally available formulation containing an inhibitor of Bruton agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity…
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National Institutes of Health
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2 relations
Broader (1)
GS-4059
Receptor Tyrosine Kinase Inhibition
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Abstract 4016: Homogeneous BTK occupancy assay for pharmacodynamic assessment of GS-4059 target engagement
Helen Yu
,
H. Truong
,
+7 authors
S. Mitra
2017
Corpus ID: 79761458
Burton’s Tyrosine Kinase (BTK) plays an important role in B cell signaling, cell proliferation and survival. Hence, it is an…
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2014
2014
A new era in CLL treatment.
Melissa A. Weber
Cancer Discovery
2014
Corpus ID: 5055202
Treatment for chronic lymphocytic leukemia (CLL) is undergoing a dramatic shift: Targeted drugs are replacing the often…
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2013
2013
Abstract 2452: ONO-4059, a novel oral Bruton's tyrosine kinase (Btk) inhibitor that demonstrates potent pharmacodynamic activity through Phosphorylated Btk (P-Btk) inhibition, in addition to…
Tomoko Yasuhiro
,
T. Yoshizawa
,
+4 authors
J. Birkett
2013
Corpus ID: 72124132
Purpose: The B-cell receptor (BCR) pathway plays a central role in signal transduction pathways that regulate survival…
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