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In preclinical models, it has been reported that social defeat stress activates microglial cells in the CNS. Translocator protein… Expand Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disorder characterized by abdominal pain and abnormal bowel… Expand ONO‐2952 is a novel and selective inhibitor of translocator protein 18 kDa that reduces stress‐induced defecation and visceral… Expand ONO‐2952, a novel antagonist of translocator protein 18 kDa (TSPO), binds with high affinity to TSPO in rat brain and human tumor… Expand We have previously shown that ONO-2952, a novel 18-kDa translocator protein (TSPO) antagonist, inhibits stress-induced… Expand There remains a significant unmet clinical need for safe and effective treatments in irritable bowel syndrome (IBS), particularly… Expand on stress-induced rectal hyperalgesia and defecation in rats. Gastroenterology 2012; 142: S813–4. 3. Mitsui K. Anti stress… Expand Abbreviations This article has not been copyedited and formatted. The final version may differ from this version. Abstract We… Expand Accumulating evidence has shown the pathophysiological significance of the translocator protein 18 kDa (TSPO) in the central… Expand PURPOSE
To investigate safety, tolerability, and pharmacokinetic properties of single and multiple doses of novel translocator… Expand