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ONO-2952

National Institutes of Health

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2 relations

Broader (2)

CyclopropanesHeterocyclic Compounds, 4 or More Rings

Papers overview

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2018
2018
Translocator protein 18kDa antagonist ameliorates stress‐induced stool abnormality and abdominal pain in rodent stress models
Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disorder characterized by abdominal pain and abnormal bowel… 
2017
2017
Brain translocator protein occupancy by ONO‐2952 in healthy adults: A Phase 1 PET study using [11C]PBR28
ONO‐2952, a novel antagonist of translocator protein 18 kDa (TSPO), binds with high affinity to TSPO in rat brain and human tumor… 
2017
2017
Editorial: ONO‐2952 in irritable bowel syndrome with diarrhoea
There remains a significant unmet clinical need for safe and effective treatments in irritable bowel syndrome (IBS), particularly… 
2017
2017
Editorial: ONO‐2952 in irritable bowel syndrome with diarrhoea – authors’ reply
on stress-induced rectal hyperalgesia and defecation in rats. Gastroenterology 2012; 142: S813–4. 3. Mitsui K. Anti stress… 
2015
2015
Mo1287 Efficacy of ONO-2952, a Novel and Selective Antagonist of Translocator Protein: Results of a Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Phase II Study (RESTORE-4)
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