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OBSCN gene

Known as: KIAA1556, OBSCURIN, obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 
National Institutes of Health

Related topics

Related topics

2 relations
obscurin-MLCKrho guanine nucleotide exchange factor p115

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Breast Cancer Clinical Trial of Chemotherapy and Trastuzumab: Potential Tool to Identify Cardiac Modifying Variants of Dilated Cardiomyopathy
Doxorubicin and the ERBB2 targeted therapy, trastuzumab, are routinely used in the treatment of HER2+ breast cancer. In mouse… 
2017
2017
Studies into the structure and function of various domains of obscurin and titin
2016
2016
Loss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffness
Obscurins are a family of RhoGEF-containing proteins with tumor and metastasis suppressing roles in breast epithelium… 
2016
2016
Immunohistochemical studies of obscurin in failing and non-failing human hearts
2015
2015
6C.01: CULLIN-3 MUTATIONS LEADING TO SKIPPING OF EXON 9 ARE RESPONSIBLE FOR SEVERE CASES OF FAMILIAL HYPERKALAEMIC HYPERTENSION
Objective: Familial hyperkalaemic hypertension (FHHt) also known as Gordon syndrome is a rare form of hypertension. Design and… 
2015
2015
Chemical shift assignments for the Ig2 domain of human obscurin A
The giant sarcomeric protein obscurin (~720 kDa) is an essential contributor to myofibrillogenesis and acts as the only known… 
2014
2014
A Mutation in VEGFC, a Ligand for VEGFR3, is Associated with Autosomal Dominant Milroy-like Primary Lymphedema Running title: Mutation in VEGFC Causes Primary Lymphedema
KG, PSM: Department of Clinical Sciences, St George's University of London, London SW17 0RE, UK DS, GR, AvI, SSM: Hubrecht… 
2009
2009
TC10 controls human myofibril organization and is activated by the sarcomeric RhoGEF obscurin
The contractile activity of striated muscle depends on myofibrils that are highly ordered macromolecular complexes. The protein… 
Highly Cited
2006
Highly Cited
2006
Obscurin is required for the lateral alignment of striated myofibrils in zebrafish
Obscurin/obscurin‐MLCK is a giant sarcomere‐associated protein with multiple isoforms whose interactions with titin and small… 
2004
2004
Analysis of a 108-kb Region of the Saccharopolyspora spinosa Genome Covering the Obscurin Polyketide Synthase Locus
A 108-kb genomic DNA region of Saccharopolyspora spinosa NRRL 18395, producer of the agriculturally important insecticidal… 
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