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rho guanine nucleotide exchange factor p115

Known as: RhoGEF, Rho Guanine Nucleotide Exchange Factor 1, Rho GEF 1 
Ubiquitously expressed by human ARHGEF1 Gene as alternative isoforms 1 (912-aa, 102-kD) and 2 (879-aa), cytoplasmic Rho Guanine Nucleotide Exchange… 
National Institutes of Health

Related topics

Related topics

8 relations
ARHGEF1 geneARHGEF1 wt AlleleCell Cycle ControlMyosin Phosphatase Pathway

Broader (1)

Rho Guanine Nucleotide Exchange Factors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Arhgef1 Plays a Vital Role in Platelet Function and Thrombogenesis
Background Platelets are the cellular mediators of hemostasis and thrombosis, and their function is regulated by a number of… 
2014
2014
Superoxide Inhibits Guanine Nucleotide Exchange Factor (GEF) Action on Ras, but not on Rho, through Desensitization of Ras to GEF
Ras and Rho GTPases are molecular switches for various vital cellular signaling pathways. Overactivation of these GTPases often… 
2013
2013
HspB1 silences translation of PDZ-RhoGEF by enhancing miR-20a and miR-128 expression to promote neurite extension
2013
2013
Modification of p115RhoGEF Ser(330) regulates its RhoGEF activity.
2011
2011
Role of p115RhoGEF in the regulation of extracellular Ca2+‐induced choline kinase activation and prostate cancer cell proliferation
Ca2+ is a ubiquitous cellular signal which plays a central role in the regulation of cell function. To understand aberrant… 
2006
2006
Cross-Talk between Gs-and Gq-Coupled Pathways in Regulation of Interleukin-4 by A 2 B Adenosine Receptors in Human Mast Cells
Human mast cells express functional A2A and A2B adenosine receptors. However, only stimulation of A2B, not A2A, leads to… 
2005
2005
The Lsc RhoGEF mediates signaling from thromboxane A2 to actin polymerization and apoptosis in thymocytes
The Lsc RhoGEF (also known as p115‐RhoGEF) is a GTP exchange factor (GEF), an activator of GTPases of the Rho family. Lsc has a… 
2005
2005
Functional consequences of G alpha 13 mutations that disrupt interaction with p115RhoGEF.
The G-protein alpha subunit, alpha(13), regulates cell growth and differentiation through the monomeric Rho GTPase. Alpha(13… 
2002
2002
Functional Analysis of Cdc42 Residues Required for Guanine Nucleotide Exchange*
Guanine nucleotide exchange factors (GEFs) directly engage small GTPases to facilitate the exchange of bound GDP for GTP, leading… 
1999
1999
Fidelity of G protein b-subunit association by the G protein g-subunit-like domains of RGS 6 , RGS 7 , and RGS 11
Several regulators of G protein signaling (RGS) proteins contain a G protein g-subunit-like (GGL) domain, which, as we have shown… 
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