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Nuclear Receptor ROR-Gamma

Known as: Retinoid-Related Orphan Receptor-Gamma, RORC, Nuclear Receptor RZR-Gamma 
Nuclear receptor ROR-gamma (518 aa, ~58 kDa) is encoded by the human RORC gene. This protein plays a role in ligand-mediated transcriptional… 
National Institutes of Health

Related topics

Related topics

21 relations
Biologic DevelopmentCell Differentiation processCell NucleusCell Proliferation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Identification of Casz1 as a Regulatory Protein Controlling T Helper Cell Differentiation, Inflammation, and Immunity
While T helper (Th) cells play a crucial role in host defense, an imbalance in Th effector subsets due to dysregulation in their… 
2018
2018
Abstract 3753: Indoximod modulates AhR-driven transcription of genes that control immune function
The IDO pathway mediates immunosuppressive effects by metabolizing tryptophan (Trp) into kynurenine (Kyn). The depletion of Trp… 
2015
2015
Discovery of 1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide analogs as new RORC modulators.
2013
2013
Intestinal Lin−c-Kit+NKp46−CD4− Population Strongly Produces IL-22 upon IL-1β Stimulation
Small intestinal innate lymphoid cells (ILCs) regulate intestinal epithelial cell homeostasis and help to prevent pathogenic… 
2013
2013
Th17 cells, pathogenic or not? TGF-β3 imposes the embargo
Th17 cells that express lineage-specific transcription factor RORC in human (and RORγt in mice) and produce cytokines IL-17A, IL… 
2013
2013
Acute infection of mice with Clostridium difficile leads to eIF2α phosphorylation and pro‐survival signalling as part of the mucosal inflammatory response
The current study sought to delineate the gene expression profile of the host response in the caecum and colon during acute… 
2012
2012
Aryl Hydrocarbon Receptor-Mediated Perturbations in Gene Expression during Early Stages of CD4+ T-cell Differentiation
Activation of the aryl hydrocarbon receptor (AhR) by its prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), mediates… 
Highly Cited
2011
Highly Cited
2011
Epigenetic Changes at Il12rb2 and Tbx21 in Relation to Plasticity Behavior of Th17 Cells
Plasticity within Th cell populations may play a role in enabling site-specific immune responses to infections while limiting… 
2004
2004
ComPPARtmentalizing NF-κB in the gut
How do commensal gut bacteria coexist with the host without causing uncontrolled inflammation? The answer may lie in the… 
2003
2003
Molecular screening and association studies of retinoid-related orphan receptor gamma (RORC): a positional and functional candidate for type 2 diabetes.
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