FAQ

Nuclear Receptor ROR-Gamma

Known as: Retinoid-Related Orphan Receptor-Gamma, RORC, Nuclear Receptor RZR-Gamma 
Nuclear receptor ROR-gamma (518 aa, ~58 kDa) is encoded by the human RORC gene. This protein plays a role in ligand-mediated transcriptional… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2017
0102019972017

Related topics

Related topics

21 relations
Biologic DevelopmentCell Differentiation processCell NucleusCell Proliferation
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Nuclear Receptor ROR-Gamma
Cell Nucleus
Cytoplasm
Homeostasis
Cell Differentiation process
Cell Proliferation

Papers overview

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Highly Cited
2011
Highly Cited
2011
Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer.
The tumor microenvironment includes a complex network of immune T-cell subpopulations. In this study, we systematically analyzed… (More)
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Highly Cited
2011
Highly Cited
2011
TLR2 stimulation drives human naive and effector regulatory T cells into a Th17-like phenotype with reduced suppressive function.
Naturally occurring CD4(+)CD25(+)FOXP3(+) regulatory T cells suppress the activity of pathogenic T cells and prevent development… (More)
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Highly Cited
2010
Highly Cited
2010
Mast cells express IL-17A in rheumatoid arthritis synovium.
The proinflammatory cytokine IL-17A is considered a crucial player in rheumatoid arthritis (RA) pathogenesis. In experimental… (More)
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Highly Cited
2010
Highly Cited
2010
CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC.
We have previously shown that human Th17 lymphocytes are characterized by the selective expression of IL-23 receptor (IL-23R… (More)
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Highly Cited
2010
Highly Cited
2010
Role of Th17 cells in human autoimmune arthritis.
OBJECTIVE To delineate the role of Th17 cells in the pathogenesis of autoimmune arthritides. METHODS Th17 cells were analyzed… (More)
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2010
2010
Increased prevalence of T helper 17 (Th17) cells in peripheral blood and decidua in unexplained recurrent spontaneous abortion patients.
T helper 17 (Th17) cells and regulatory T (Treg) cells are two distinct subsets of CD4(+) T cells which have opposite effects on… (More)
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Highly Cited
2010
Highly Cited
2010
Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease.
BACKGROUND & AIMS Mucosal natural killer (NK) cells that produce interleukin (IL)-22 mediate intestinal homeostasis and… (More)
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Highly Cited
2009
Highly Cited
2009
Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells
Interleukin 22 (IL-22) is a member of the IL-10 cytokine family that is involved in inflammatory and wound healing processes… (More)
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Highly Cited
2008
Highly Cited
2008
IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease.
BACKGROUND A novel T helper (Th) cell lineage, Th17, that exclusively produces the proinflammatory cytokine interleukin 17 (IL17… (More)
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1997
1997
Genomic structure and chromosomal mapping of the nuclear orphan receptor ROR gamma (RORC) gene.
The nuclear orphan receptor subfamily ROR/RZR is part of the steroid and thyroid hormone/retinoid receptor superfamily and… (More)
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