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Nuclear Receptor ROR-Gamma

Known as: Retinoid-Related Orphan Receptor-Gamma, RORC, Nuclear Receptor RZR-Gamma 
Nuclear receptor ROR-gamma (518 aa, ~58 kDa) is encoded by the human RORC gene. This protein plays a role in ligand-mediated transcriptional… Expand
National Institutes of Health

Related topics

Related topics

21 relations
Biologic DevelopmentCell Differentiation processCell NucleusCell Proliferation
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses
Specialized proresolving lipid mediators reduce human T cell activation and prevent TH1 and TH17 cell differentiation from naïve… Expand
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Highly Cited
2013
Highly Cited
2013
Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora.
Aryl hydrocarbon receptor (Ahr) is crucial for the maintenance and function of group 3 innate lymphoid cells (ILCs), which are… Expand
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Highly Cited
2012
Highly Cited
2012
Mouse CD11b+Gr-1+ Myeloid Cells Can Promote Th17 Cell Differentiation and Experimental Autoimmune Encephalomyelitis
Myeloid-derived suppressor cells (MDSCs) have been a focus of recent study on tumor-mediated immune suppression. However, its… Expand
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Highly Cited
2011
Highly Cited
2011
Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells.
Follicular T helper (Tfh) cells provide critical help to B cells for germinal center (GC) formation. Mutations affecting SLAM… Expand
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Highly Cited
2011
Highly Cited
2011
Neutrophils Produce Interleukin 17A (IL-17A) in a Dectin-1- and IL-23-Dependent Manner during Invasive Fungal Infection
ABSTRACT We have previously reported that compromised interleukin 17A (IL-17A) production in the lungs increased susceptibility… Expand
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Highly Cited
2010
Highly Cited
2010
Generation of Pathogenic Th17 Cells in the Absence of TGF-β Signaling
CD4+ T-helper cells that selectively produce interleukin (IL)-17 (TH17), are critical for host defence and autoimmunity. Although… Expand
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Highly Cited
2009
Highly Cited
2009
IL-27 Blocks RORc Expression to Inhibit Lineage Commitment of Th17 Cells
IL-27 is secreted by APCs in response to inflammatory stimuli and exerts a proinflammatory Th1-enhancing activity but also has… Expand
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Highly Cited
2009
Highly Cited
2009
Down-regulation of Gfi-1 expression by TGF-β is important for differentiation of Th17 and CD103+ inducible regulatory T cells
Growth factor independent 1 (Gfi-1), a transcriptional repressor, is transiently induced during T cell activation. Interleukin… Expand
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Highly Cited
2008
Highly Cited
2008
TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function
T helper cells that produce IL-17 (TH17 cells) promote autoimmunity in mice and have been implicated in the pathogenesis of human… Expand
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Highly Cited
2007
Highly Cited
2007
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
After activation, CD4+ helper T (TH) cells differentiate into distinct effector subsets that are characterized by their unique… Expand
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