Share This Author
Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin.
Surface hydrophobin prevents immune recognition of airborne fungal spores
It is shown that the surface layer on the dormant conidia masks their recognition by the immune system and hence prevents immune response, and also immunologically silences airborne moulds.
Cutting Edge: Human CD4+CD25+ T Cells Restrain the Maturation and Antigen-Presenting Function of Dendritic Cells1
- N. Misra, J. Bayry, S. Lacroix-Desmazes, M. Kazatchkine, S. Kaveri
- BiologyJournal of Immunology
- 15 April 2004
It is shown that regulatory T cells render the DC inefficient as APCs despite prestimulation with CD40 ligand, and this effect was marginally reverted by neutralizing Abs to TGF-β and reduced expression of costimulatory molecules in DC.
Expansion of CD4+CD25+ regulatory T cells by intravenous immunoglobulin: a critical factor in controlling experimental autoimmune encephalomyelitis.
It is shown that prophylactic infusion of IVIg prevents the development of experimental autoimmune encephalomyelitis (EAE), an accepted animal model for multiple sclerosis (MS), and the protection was Treg-mediated because IVIG failed to protect against EAE in mice that were depleted of the Treg population.
Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies.
Inhibition of maturation and function of dendritic cells by intravenous immunoglobulin.
It is shown that IVIg inhibits the differentiation and maturation of DCs in vitro and abrogates the capacity of mature DC to secrete interleukin-12 (IL-12) on activation while enhancing IL-10 production.
CISH and susceptibility to infectious diseases.
The next generation of scientists will be able to assess the impact of climate change on innovation and improve the quality of life of people around the world.
Self-reactive antibodies (natural autoantibodies) in healthy individuals.
Intravenous Immunoglobulin: An Update on the Clinical Use and Mechanisms of Action
Initially used as a replacement therapy for immunodeficiency diseases, intravenous immunoglobulin (IVIg) is now widely used for a number of autoimmune and inflammatory diseases. Considerable progress…
IVIG-mediated effector functions in autoimmune and inflammatory diseases
Experimental and clinical data provide an indicator that the therapeutic benefit of IVIG therapy is due to several mutually non-exclusive mechanisms affecting soluble mediators as well as cellular components of the immune system.