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Cutting Edge: Human CD4+CD25+ T Cells Restrain the Maturation and Antigen-Presenting Function of Dendritic Cells1
TLDR
It is shown that regulatory T cells render the DC inefficient as APCs despite prestimulation with CD40 ligand, and this effect was marginally reverted by neutralizing Abs to TGF-β and reduced expression of costimulatory molecules in DC. Expand
Surface hydrophobin prevents immune recognition of airborne fungal spores
TLDR
It is shown that the surface layer on the dormant conidia masks their recognition by the immune system and hence prevents immune response, and also immunologically silences airborne moulds. Expand
Expansion of CD4+CD25+ regulatory T cells by intravenous immunoglobulin: a critical factor in controlling experimental autoimmune encephalomyelitis.
TLDR
It is shown that prophylactic infusion of IVIg prevents the development of experimental autoimmune encephalomyelitis (EAE), an accepted animal model for multiple sclerosis (MS), and the protection was Treg-mediated because IVIG failed to protect against EAE in mice that were depleted of the Treg population. Expand
Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies.
TLDR
Th17 cells are associated with the pathogenesis of several autoimmune and inflammatory diseases, such as rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, psoriasis, inflammatory bowel disease, and allergy and asthma and the various therapeutic strategies under investigation to target them are discussed. Expand
CISH and susceptibility to infectious diseases.
TLDR
The next generation of scientists will be able to assess the impact of climate change on innovation and improve the quality of life of people around the world. Expand
Self-reactive antibodies (natural autoantibodies) in healthy individuals.
TLDR
The current knowledge on the physicochemical and functional properties of NAA in man, and the use of N AA for therapeutic intervention is focused on. Expand
Src Homology 3-interacting Domain of Rv1917c of Mycobacterium tuberculosis Induces Selective Maturation of Human Dendritic Cells by Regulating PI3K-MAPK-NF-κB Signaling and Drives Th2 Immune
TLDR
Results indicate that Rv1917c facilitates a shift in the ensuing immunity toward the Th2 phenotype and could aid in immune evasion by mycobacteria. Expand
Inhibition of maturation and function of dendritic cells by intravenous immunoglobulin.
TLDR
It is shown that IVIg inhibits the differentiation and maturation of DCs in vitro and abrogates the capacity of mature DC to secrete interleukin-12 (IL-12) on activation while enhancing IL-10 production. Expand
Human monoclonal antibodies reactive to oligodendrocytes promote remyelination in a model of multiple sclerosis.
TLDR
The results are consistent with the hypothesis that CNS-reactive mAbs, part of the normal Ig repertoire in humans, may help repair and protect the CNS from pathogenic immune injury, and further challenge the premise that Abs that bind OLs are necessarily pathogenic. Expand
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