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Nonclinical Study

Known as: Preclinical Study, Preclinical Testing, preclinical studies 
Research using animals to find out if a drug, procedure, or treatment is likely to be useful. Preclinical studies take place before any testing in… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Initial testing (stage 1) of the curaxin CBL0137 by the pediatric preclinical testing program
CBL0137 is a novel drug that modulates FAcilitates Chromatin Transcription (FACT), resulting in simultaneous nuclear factor‐κB… 
2015
2015
Initial testing (stage 1) of the anti‐microtubule agents cabazitaxel and docetaxel, by the Pediatric Preclinical Testing Program
Although microtubule‐destabilizing agents (principally vincristine) are in common use in pediatric oncology, the microtubule… 
2013
2013
Toll-Like Receptor 5-Dependent Immunogenicity and Protective Efficacy of a Recombinant Fusion Protein Vaccine Containing the Nontoxic Domains of Clostridium difficile Toxins A and B and Salmonella…
ABSTRACT Clostridium difficile is a spore-forming bacillus that produces toxin-mediated enteric disease. C. difficile expresses… 
2013
2013
A new model for preclinical testing of dermal substitutes for human skin reconstruction
BackgroundCurrently, acellular dermal substitutes used for skin reconstruction are usually covered with split-thickness skin… 
Review
2012
Review
2012
Balancing Tissue and Tumor Formation in Regenerative Medicine
A set of general principles can guide preclinical testing strategies for evaluating the tumorigenicity of regenerative medicine… 
2007
2007
Overlapping human leukocyte antigen class I/II binding peptide vaccine for the treatment of patients with stage IV melanoma
MPS160 (GRAMLGTHTMEVTV) is a glycoprotein 100‐derived melanoma peptide that contains overlapping human leukemic antigen A2‐, DR53… 
Review
2006
Review
2006
Current progress in the development of HIV vaccines.
The greatest hope for controlling the expanding HIV epidemic is the development of a preventive HIV vaccine. Despite almost… 
2006
2006
Correlation of cerebral metabolites with functional outcome in experimental primate stroke using in vivo 1H-magnetic resonance spectroscopy.
BACKGROUND AND PURPOSE Ensuring the translatability of primate stroke models is critical for preclinical testing of… 
2005
2005
Intranasal Delivery of Group B Meningococcal Native Outer Membrane Vesicle Vaccine Induces Local Mucosal and Serum Bactericidal Antibody Responses in Rabbits
ABSTRACT We have previously shown that intranasal immunization of mice with meningococcal native outer membrane vesicles (NOMV… 
2000
2000
Use of cotton rats for preclinical evaluation of measles vaccines.
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