Nonclinical Study

Known as: Preclinical Study, Preclinical Testing, preclinical studies 
Research using animals to find out if a drug, procedure, or treatment is likely to be useful. Preclinical studies take place before any testing in… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1973-2018
020040019732018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
MAGE A3, which belongs to the family of cancer-testis antigens, is an attractive target for adoptive therapy given its… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2011
Highly Cited
2011
The proportion of the human gut bacterial community that is recalcitrant to culture remains poorly defined. In this report, we… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2010
Highly Cited
2010
The lifetime prevalence (∼16%) and the economic burden ($100 billion annually) associated with major depressive disorder (MDD… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2010
Highly Cited
2010
BACKGROUND MLN8237 is a small molecule inhibitor of Aurora Kinase A (AURKA) that is currently in early phase clinical testing… (More)
Is this relevant?
Highly Cited
2007
Highly Cited
2007
BACKGROUND The Pediatric Preclinical Testing Program (PPTP) is an initiative supported by the National Cancer Institute (NCI) to… (More)
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Neuropathic pain is a debilitating condition affecting millions of people around the world and is defined as pain that follows a… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
RAS mutations are common in myeloid malignancies; however, it is not known whether oncogenic RAS can initiate leukemia. We show… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
A number of recent preclinical studies have sparked interest in the concept of exploiting conventional chemotherapeutic drugs as… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2000
Highly Cited
2000
At least 70% of small cell lung cancers express the Kit receptor tyrosine kinase and its ligand, stem cell factor (SCF). Numerous… (More)
  • figure 2
  • figure 1
  • figure 4
  • figure 3
  • figure 5
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Despite the extensive interest in NADPH:quinone oxidoreductase (NQO1, DT-diaphorase), there is little immunohistochemical… (More)
Is this relevant?