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Nitroso Carcinogen

A compound with carcinogenic properties that contains an -NO group. (NCI05)
National Institutes of Health

Papers overview

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2004
2004
Immuno-slot-blot: A highly sensitive immunoassay for the quantitation of carcinogen-modified nucleosides in DNA
SummaryWe have established a highly sensitive immuno-slot-blot (ISB) procedure that can be routinely applied for detection and… 
2000
2000
Suppression of ethylnitrosourea-induced schwannoma development involves elimination of neu/erbB-2 mutant premalignant cells in the resistant BDIV rat strain.
Contrary to the response of rats of the highly sensitive inbred strain BDIX, BDIV rats are resistant to the induction of… 
1991
1991
Monoclonal antibody-based, selective isolation of DNA fragments containing an alkylated base to be quantified in defined gene sequences.
We have established a sensitive, monoclonal antibody (Mab)-based procedure permitting the selective enrichment of sequences… 
1990
1990
Repair of O6-ethylguanine in DNA protects rat 208F cells from tumorigenic conversion by N-ethyl-N-nitrosourea.
O6-Ethylguanine (O6-EtGua) is one of about a dozen different alkylation products formed in the DNA of cells exposed to the… 
1988
1988
Modifying role of vitamins on the mutagenic action of N-methyl-N'-nitro-N-nitrosoguanidine.
Several vitamin compounds have been tested for their ability to suppress the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine… 
1983
1983
Similar rate of O6-ethylguanine elimination from DNA in normal human fibroblast and xeroderma pigmentosum cell strains not transformed by SV40.
Using a highly specific rabbit antiserum (E3) directed against O6-ethyldeoxyguanosine in a competitive radioimmunoassay, we have… 
1980
1980
Increased responsiveness of the hepatic guanylate cyclase-guanosine 3',5'-monophosphate system to nitrosoguanidine following partial hepatectomy.
1980
1980
N6-(Methylnitroso)adenosine: a carcinogen from a nucleic acid component.
Substituted aminopurines in nucleic acids may be nitrosated to yield carcinogenic nitrosaminopurines. To investigate this… 
1979
1979
Induction of reproductive system tumors in mice by N6‐(methylnitroso)‐adenosine and a tumorigenic effect of its combined precursors
Interaction of the naturally‐occurring nucleoside, N6‐methyl adenosine, with nitrite, a reaction that occurs readily under acidic… 
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