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Nitrosamine Metabolism

Nitrosamine Metabolism involves important cellular biochemical detoxification reactions that chemically modify the N-nitroso derivatives of secondary… 
National Institutes of Health

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Carcinogen ResistanceCarcinogensResistance Processhost defense

Papers overview

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Highly Cited
2006
Highly Cited
2006
Genes Involved in DNA Repair and Nitrosamine Metabolism and Those Located on Chromosome 14q32 Are Dysregulated in Nasopharyngeal Carcinoma
Polymorphisms in nitrosamine metabolism, DNA repair, and immune response genes have been associated with nasopharyngeal carcinoma… 
Highly Cited
2002
Highly Cited
2002
CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism.
Oesophageal cancer is one of the most common and lethal malignancies in the world. Despite many efforts, treatment is still… 
Highly Cited
1998
Highly Cited
1998
Characterization of xenobiotic-metabolizing enzymes and nitrosamine metabolism in the human esophagus.
Esophageal cancer has been associated with tobacco smoking, and nitrosamines are possible causative agents for this cancer. The… 
Highly Cited
1993
Highly Cited
1993
High variability of nitrosamine metabolism among individuals: Role of cytochromes P450 2A6 and 2E1 in the dealkylation of N‐nitrosodimethylamine and N‐nitrosodiethylamine in mice and humans
We undertook this study to answer several questions regarding nitrosamine metabolism. Kinetics of nitrosamine metabolism showed… 
Highly Cited
1992
Highly Cited
1992
Effects of phenethyl isothiocyanate, a carcinogenesis inhibitor, on xenobiotic-metabolizing enzymes and nitrosamine metabolism in rats.
Phenethyl isothiocyanate (PEITC), a constituent of cruciferous vegetables, has been shown to inhibit chemical carcinogenesis… 
Review
1990
Review
1990
Cytochrome P450IIE1: roles in nitrosamine metabolism and mechanisms of regulation.
Highly Cited
1988
Highly Cited
1988
Effect of diallyl sulfide on rat liver microsomal nitrosamine metabolism and other monooxygenase activities.
It has been reported that p.o. administration of diallyl sulfide (DAS), a naturally occurring component of garlic (Allium sativum… 
Highly Cited
1987
Highly Cited
1987
Stabilization of cytochrome P450j messenger ribonucleic acid in the diabetic rat.
Cytochrome P450j, an enzyme involved in nitrosamine metabolism, is expressed in hepatic, pulmonary, and renal tissues and its… 
1985
1985
Oxidative dealkylation and reductive denitrosation of nitrosomethylaniline in vitro.
Highly Cited
1983
Highly Cited
1983
High-affinity nitrosamine dealkylase system in rat liver microsomes and its induction by fasting.
In order to elucidate the enzymic basis of nitrosamine metabolism, the in vitro metabolism of nitrosamines by rat liver… 
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