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Niridazole

Known as: 2-Imidazolidinone, 1-(5-nitro-2-thiazolyl)-, Niridazole [Chemical/Ingredient] 
An antischistosomal agent that has become obsolete.
National Institutes of Health

Related topics

Related topics

18 relations

Narrower (8)

4'-methylniridazole4,5-dehydroniridazole4-hydroxyniridazole4-ketoniridazole

Broader (2)

AmebicidesSchistosomicides
In BloodPoisoning by anthelminthicsagonistsanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Research and development of antischistosomal drugs in the People's Republic of China a 60-year review.
Highly Cited
1989
Highly Cited
1989
The popliteal lymph node assay in mice to screen for the immune disregulating potential of chemicals--a preliminary study.
1984
1984
Validation of the Salmonella (SV50)/arabinose-resistant forward mutation assay system with 26 compounds.
1983
1983
Reductive metabolism of niridazole by adult Schistosoma mansoni. Correlation with covalent drug binding to parasite macromolecules.
Niridazole, an antischistosomal nitrothiazole derivative, is metabolized by adult Schistosoma mansoni to one or more reactive… 
Highly Cited
1981
Highly Cited
1981
Evidence for the existence of a family of bacterial nitroreductases capable of activating nitrated polycyclics to mutagens.
A derivative of Salmonella typhimurium TA98 which does not respond to the potent mutagenicity of 1,8-dinitropyrene is described… 
Highly Cited
1980
Highly Cited
1980
Relative importance of bacterial and mammalian nitroreductases for niridazole mutagenesis.
Niridazole is a nitrothiazole anthelmintic agent used to treat schistosomiasis. Its antibacterial activity was found to require… 
Highly Cited
1975
Highly Cited
1975
Niridazole. II. A potent long-acting suppressant of cellular hypersensitivity.
Niridazole, a human anthelminthic drug, is shown to be a potent long-acting suppressor of delayed hypersensitivity. Much lower… 
1975
1975
Suppression of delayed hypersensitivity in schistosome-infected patients by niridazole.
Niridazole, an anti-parasitic drug, suppresses manifestations of delayed hypersensitivity and retards allograft rejection in… 
Highly Cited
1973
Highly Cited
1973
Studies with the schistosomicide oxamniquine (UK-4271). I. Activity in rodents and in vitro.
1969
1969
METABOLISM OF NIRIDAZOLE IN VARIOUS SPECIES, INCLUDING MAN
Both in the course of biological and clinical studies with a drug as well as when the preparation is actually being employed in… 
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