New Approaches to Brain Tumor Therapy Consortium
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The signal transduction pathways of epidermal growth factor receptor and Ras are both important in the growth of… Expand Cilengitide is a selective integrin inhibitor that is well tolerated and has demonstrated biologic activity in patients with… Expand Penicillamine is an oral agent used to treat intracerebral copper overload in Wilson's disease. Copper is a known regulator of… Expand ONYX-015 is an oncolytic virus untested as a treatment for malignant glioma. The NABTT CNS Consortium conducted a dose-escalation… Expand BACKGROUND
Primary intraocular lymphoma (PIOL) is a subset of primary central nervous system lymphoma (PCNSL) in which lymphoma… Expand The primary objective of this study was to determine the proportion of patients exhibiting a radiographic response in a cohort of… Expand PURPOSE
A multicenter, phase II study of single-agent, intravenous methotrexate in newly diagnosed non-AIDS-related primary CNS… Expand PURPOSE
A preliminary evaluation of the efficacy of irinotecan in patients with malignant glioma demonstrated modest activity. A… Expand BACKGROUND: There is extraordinary interest in developing angiosuppressive agents for cancer treatment. Several new agents appear… Expand BACKGROUND: Despite advances in neuro-imaging, neurosurgery, radiation therapy, and chemotherapy, limited progress has been made… Expand