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Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis
- Josep Dalmau, E. Lancaster, E. Martinez-Hernandez, M. Rosenfeld, R. Balice-Gordon
- The Lancet Neurology
- 31 January 2011
Since its discovery in 2007, the encephalitis associated with antibodies against the N-methyl-D-aspartate receptor (NMDAR) has entered the mainstream of neurology and other disciplines. Most patients… Expand
Paraneoplastic anti–N‐methyl‐D‐aspartate receptor encephalitis associated with ovarian teratoma
To report the autoantigens of a new category of treatment‐responsive paraneoplastic encephalitis.
Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients.
- S. Gultekin, M. Rosenfeld, R. Voltz, J. Eichen, J. Posner, J. Dalmau
- Brain : a journal of neurology
- 1 July 2000
Paraneoplastic limbic encephalitis (PLE) is a rare disorder characterized by personality changes, irritability, depression, seizures, memory loss and sometimes dementia. The diagnosis is difficult… Expand
Anti–N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis in children and adolescents
To report the clinical features of anti–N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis in patients ≤ 18 years old.
Paraneoplastic syndromes of the CNS
Major advances in the management of paraneoplastic neurologic disorders (PND) include the detection of new antineuronal antibodies, the improved characterisation of known syndromes, the discovery of… Expand
Clinical analysis of anti-Ma2-associated encephalitis.
Increasing experience indicates that anti-Ma2-associated encephalitis differs from classical paraneoplastic limbic or brainstem encephalitis, and therefore may be unrecognized. To facilitate its… Expand
HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and sex-lethal
A neuronal antigen (HuD) recognized by the sera of patients with antibody-associated paraneoplastic encephalomyelitis has been isolated by screening a lambda cerebellar expression library. The… Expand
Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates.
We report seven patients, six from a single institution, who developed subacute limbic encephalitis initially considered of uncertain aetiology. Four patients presented with symptoms of hippocampal… Expand
A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme
Preclinical studies indicate autophagy inhibition with hydroxychloroquine (HCQ) can augment the efficacy of DNA-damaging therapy. The primary objective of this trial was to determine the maximum… Expand
Small-cell lung cancer, paraneoplastic cerebellar degeneration and the Lambert-Eaton myasthenic syndrome.
Several cancers, especially lung, ovarian and breast, can cause paraneoplastic cerebellar degeneration. The presence of different antineuronal antibodies associated with different cancers and… Expand