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Negative Elongation Factor B, human

Known as: Negative Elongation Factor Polypeptide B, Negative Elongation Factor B, cofactor of BRCA1 protein, human 
Negative elongation factor B (580 aa, ~66 kDa) is encoded by the human NELFB gene. This protein is involved in the negative regulation of transcript… Expand
National Institutes of Health

Related topics

Related topics

9 relations
Cell NucleusGenes, RegulatorNELFB geneNELFB wt Allele
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Broader (1)

negative elongation factor

Papers overview

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2019
2019
Negative elongation factor is essential for endometrial function.
Pausing of RNA polymerase II (Pol II) during early transcription, mediated by the negative elongation factor (NELF) complex… Expand
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2016
2016
Architecture and RNA binding of the human negative elongation factor
Transcription regulation in metazoans often involves promoter-proximal pausing of RNA polymerase (Pol) II, which requires the 4… Expand
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2015
2015
Structural and functional studies on the negative elongation factor
In many metazoans RNA polymerase II is stably paused after transcribing 20-60 nucleotides of a gene and awaits controlled release… Expand
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Review
2015
Review
2015
Translational Initiation at a Non-AUG Start Codon for Human and Mouse Negative Elongation Factor-B
Negative elongation factor (NELF), a four-subunit protein complex in metazoan, plays an important role in regulating promoter… Expand
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2014
2014
Negative Elongation Factor Controls Energy Homeostasis in Cardiomyocytes
SUMMARY Negative elongation factor (NELF) is known to enforce promoter-proximal pausing of RNA polymerase II (Pol II), a… Expand
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2014
2014
A Kinase-Independent Activity of Cdk9 Modulates Glucocorticoid Receptor-Mediated Gene Induction
A gene induction competition assay has recently uncovered new inhibitory activities of two transcriptional cofactors, NELF-A and… Expand
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2013
2013
A Conserved Protein Motif Is Required for Full Modulatory Activity of Negative Elongation Factor Subunits NELF-A and NELF-B in Modifying Glucocorticoid Receptor-regulated Gene Induction Properties*
Background: Understanding glucocorticoid receptor (GR)-regulated gene transcription requires detailed description of cofactor… Expand
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2011
2011
Genetic and Genomic Analyses of RNA Polymerase II-pausing Factor in Regulation of Mammalian Transcription and Cell Growth*
Background: RNA polymerase II pausing is an important regulatory step in eukaryotic transcription. Results: Genetic ablation of… Expand
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2009
2009
Mouse Cofactor of BRCA1 (Cobra1) Is Required for Early Embryogenesis
Background Negative elongation factor (NELF) is a four-subunit protein complex conserved from Drosophila to humans. In vitro… Expand
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2009
2009
Warten auf die Transkription: Die humanen Elongationsfaktoren NELF und DSIF
The E subunit of the human heterotetrameric negative transcription elongation factor (NELFE) contains a canonical R R RNA… Expand
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