FAQ

Negative Elongation Factor B, human

Known as: Negative Elongation Factor Polypeptide B, Negative Elongation Factor B, cofactor of BRCA1 protein, human 
Negative elongation factor B (580 aa, ~66 kDa) is encoded by the human NELFB gene. This protein is involved in the negative regulation of transcript… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2004-2018
01220042018

Related topics

Related topics

9 relations
Cell NucleusGenes, RegulatorNELFB geneNELFB wt Allele
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Broader (1)

negative elongation factor

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Negative Elongation Factor B, human
Cell Nucleus
Genes, Regulator
Transcriptional Regulation
Transcription Repressor/Corepressor
Transcriptional Repression

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Gene-Specific Genetic Complementation between Brca1 and Cobra1 During Mouse Mammary Gland Development
Germ-line mutations in breast cancer susceptibility gene, BRCA1, result in familial predisposition to breast and ovarian cancers… (More)
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2009
2009
Mouse Cofactor of BRCA1 (Cobra1) Is Required for Early Embryogenesis
BACKGROUND Negative elongation factor (NELF) is a four-subunit protein complex conserved from Drosophila to humans. In vitro… (More)
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2008
2008
Deregulation of cofactor of BRCA1 expression in breast cancer cells.
Cofactor of BRCA1 (COBRA1) is an integral component of the human negative elongation factor (NELF), a four-subunit protein… (More)
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2007
2007
Cofactor of BRCA1 modulates androgen-dependent transcription and alternative splicing.
Transcriptional activity of nuclear receptors (NRs) is influenced by a large number of coregulators that exert their actions… (More)
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2007
2007
Regulation of clustered gene expression by cofactor of BRCA1 (COBRA1) in breast cancer cells
Eucaryotic genes that are coordinately expressed tend to be clustered. Furthermore, gene clusters across chromosomal regions are… (More)
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2007
2007
Concerted Transcriptional Regulation by BRCA1 and COBRA1 in Breast Cancer Cells
Cofactor of BRCA1 (COBRA1) was first identified as a protein that binds to the breast cancer susceptibility gene product BRCA1… (More)
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2006
2006
Cofactor of BRCA1: a novel transcription factor regulator in upper gastrointestinal adenocarcinomas.
Cofactor of BRCA1 (COBRA1) is a newly characterized member of the negative elongation factor (NELF) complex. In this work, we… (More)
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2004
2004
COBRA1 inhibits AP-1 transcriptional activity in transfected cells.
Mutations in the breast cancer susceptibility gene (BRCA1) account for a significant proportion of hereditary breast and ovarian… (More)
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2004
2004
Characterization of COBRA1 in human breast cancer cell lines using a new polyclonal antibody against COBRA1.
Mutations in the breast cancer susceptibility gene BRCA1 predispose individuals to breast and ovarian cancers. Cofactor of BRCA1… (More)
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