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NXL 104

Known as: NXL-104, NXL104 
National Institutes of Health

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1 relation

Broader (1)

avibactam

Papers overview

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2014
2014
Inactivation of TEM-1 by avibactam (NXL-104): insights from quantum mechanics/molecular mechanics metadynamics simulations.
The fast and constant development of drug-resistant bacteria represents a serious medical emergence. To overcome this problem… 
2012
2012
Anti-anaerobic activity of a new β-lactamase inhibitor NXL104 in combination with β-lactams and metronidazole.
2012
2012
Activity of Ceftaroline-Avibactam Tested Against Multidrug-Resistant Enterobacteriaceae and Methicillin-Resistant Staphylococcus aureus Collected from USA Hospitals in 2011
• Among 337 Enterobacter spp. strains, 97.3% were inhibited by ceftarolineavibactam at ≤0.5 mg/L. Meropenem (MIC 90, ≤0.06 mg/L… 
2011
2011
NXL104, un nouvel inhibiteur de β-lactamases à large spectre
2011
2011
X-ray Crystal Structure of the Acinetobacter baumannii OXA-24/40 Class D Carbapenemase Inhibited by NXL104
2011
2011
β-Lactamase Inhibitor NXL104 Helps Overcome Resistance of Pathogens
When used with ceftazidime or other β-lactam antibiotics, NXL104, a potent inhibitor of β-lactamase enzymes, becomes a powerful… 
2011
2011
Antimicrobial Activity of Ceftazidime Avibactam (formerly NXL104) Tested Against Gram-Negative Organisms Causing Infections in Medical Centers from Europe, Latin America and the Asia-Pacific Region
E. coli (934) 58.0 88.7 97.2 99.9 100.0 – – – ESBL-phenotype (245) 29.0 69.4 91.0 99.6 100.0 – – – Klebsiella spp. (1003) 36.3 70… 
2010
2010
Potent Activity of Ceftazidime/NXL104 Tested Against Enterobacteriaceae Isolates Carrying Multiple β-lactamase Enzymes
The presence of multiple β-lactamases in a single cephalosporin-resistant isolate has been recognized as an alarming fact since… 
2009
2009
Bactericidal Activity of Ceftaroline Combined with NXL104 Against Critical Targeted Organisms Possessing Various Resistance Mechanisms
Background: Ceftaroline (CPT), a broad-spectrum cephalosporin with gram-positive activity (including anti-MRSA), was tested in… 
2008
2008
Importance of NXL104 Pharmacokinetics (PK) in the Pharmacodynamics (PD) of Ceftazidime+NXL104 Combinations in an In Vitro Hollow Fiber Infection Model
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