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NXL 104

Known as: NXL-104, NXL104 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

avibactam

Papers overview

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Review
2015
Review
2015
β-Lactam/β-Lactamase Inhibitor Combinations
Objective: To review the available evidence regarding the utility of the currently available β-lactam/β-lactamase inhibitor… 
Highly Cited
2012
Highly Cited
2012
In Vitro Antibacterial Activity of the Ceftazidime-Avibactam (NXL104) Combination against Pseudomonas aeruginosa Clinical Isolates
ABSTRACT The β-lactamase inhibitor avibactam (NXL104) displays potent inhibition of both class A and C enzymes. The in vitro… 
Highly Cited
2011
Highly Cited
2011
Activity of NXL104 in Combination with β-Lactams against Genetically Characterized Escherichia coli and Klebsiella pneumoniae Isolates Producing Class A Extended-Spectrum β-Lactamases and Class C…
ABSTRACT The novel non-β-lactam β-lactamase inhibitor NXL104, in combination with cefepime, ceftazidime, ceftriaxone… 
Highly Cited
2011
Highly Cited
2011
In Vitro Activity of Ceftazidime Combined with NXL104 versus Pseudomonas aeruginosa Isolates Obtained from Patients in Canadian Hospitals (CANWARD 2009 Study)
ABSTRACT The in vitro activity of ceftazidime in combination with NXL104 versus 470 Pseudomonas aeruginosa clinical isolates was… 
Highly Cited
2010
Highly Cited
2010
Mechanistic Studies of the Inactivation of TEM-1 and P99 by NXL104, a Novel Non-β-Lactam β-Lactamase Inhibitor
ABSTRACT NXL104 is a potent inhibitor of class A and C serine β-lactamases, including KPC carbapenemases. Native and NXL104… 
Highly Cited
2010
Highly Cited
2010
Activity of chequerboard combinations of ceftaroline and NXL104 versus beta-lactamase-producing Enterobacteriaceae.
BACKGROUND Ceftaroline is a novel oxyimino-cephalosporin, strongly active against methicillin-resistant staphylococci and… 
Highly Cited
2010
Highly Cited
2010
Evaluation of Ceftazidime and NXL104 in Two Murine Models of Infection Due to KPC-Producing Klebsiella pneumoniae
ABSTRACT We evaluated the efficacy of NXL104, a novel β-lactamase inhibitor, in combination with ceftazidime (CAZ) in two murine… 
Highly Cited
2009
Highly Cited
2009
In vitro activity of the β-lactamase inhibitor NXL104 against KPC-2 carbapenemase and Enterobacteriaceae expressing KPC carbapenemases
Background NXL104 is a novel-structure β-lactamase inhibitor with potent activity against both class A and class C enzymes. Among… 
Highly Cited
2009
Highly Cited
2009
In Vitro Activity of NXL104 in Combination with β-Lactams against Klebsiella pneumoniae Isolates Producing KPC Carbapenemases
Klebsiella pneumoniae isolates producing class A KPC carbapenemases (KPC-Kp) are spreading at an alarming rate around the world… 
Highly Cited
2008
Highly Cited
2008
NXL104 combinations versus Enterobacteriaceae with CTX-M extended-spectrum beta-lactamases and carbapenemases.
BACKGROUND The beta-lactamase landscape is changing radically, with CTX-M types now the most prevalent extended-spectrum beta… 
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