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NVP-TAE684

Known as: TAE684 
 
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
The synthesis, preclinical profile, and in vivo efficacy in rat xenograft models of the novel and selective anaplastic lymphoma… Expand
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Highly Cited
2011
Highly Cited
2011
Anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKI), including crizotinib, are effective treatments in preclinical… Expand
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Highly Cited
2011
Highly Cited
2011
Mutations in the kinase domain of ALK (anaplastic lymphoma kinase) have recently been shown to be important for the progression… Expand
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Highly Cited
2011
Highly Cited
2011
Purpose: EML4–ALK fusions define a subset of lung cancers that can be effectively treated with anaplastic lymphoma kinase (ALK… Expand
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Highly Cited
2011
Highly Cited
2011
The echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion oncogene represents a… Expand
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Highly Cited
2010
Highly Cited
2010
The ALK kinase inhibitor crizotinib (PF-02341066) is clinically effective in patients with ALK-translocated cancers, but its… Expand
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Highly Cited
2010
Highly Cited
2010
Genetic rearrangements of the anaplastic lymphoma kinase (ALK) kinase occur in 3% to 13% of non-small cell lung cancer patients… Expand
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Highly Cited
2008
Highly Cited
2008
Purpose: The EML4-ALK fusion gene has been detected in ∼7% of Japanese non-small cell lung cancers (NSCLC). We determined the… Expand
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Highly Cited
2008
Highly Cited
2008
Neuroblastoma, an embryonal tumour of the peripheral sympathetic nervous system, accounts for approximately 15% of all deaths due… Expand
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Highly Cited
2007
Highly Cited
2007
Constitutive overexpression and activation of NPM-ALK fusion protein [t(2:5)(p23;q35)] is a key oncogenic event that drives the… Expand
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