Skip to search formSkip to main contentSkip to account menu

NVP-TAE684

Known as: TAE684 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Pyrimidines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Abstract 3161: TPX-0005, an ALK/ROS1/TRK inhibitor, overcomes multiple resistance mechanisms by targeting SRC/FAK signaling
ALK, ROS1, and TRK inhibitors have achieved marked efficacy in treating cancer patients expressing abnormal ALK, ROS1 or NTRK… 
2015
2015
Abstract 3582: Epidermal growth factor receptor and anaplastic lymphoma kinase bypass signaling in oral squamous cell carcinomain vivo
Oral squamous cell carcinoma (OSCC) is an insidious disease with poor prognosis. This is due to invasive disease that is… 
2013
2013
High Response Rates To Crizotinib In Advanced, Chemoresistant ALK+ Lymphoma Patients
![Graphic][1] In hematological disorders ALK expression is present in >50% of Anaplastic Large Cell Lymphomas (ALCL) as a… 
2012
2012
Cancer Therapy : Preclinical See commentary by Crystal and Shaw , p . 4479 Differential Protein Stability and ALK Inhibitor Sensitivity of EML 4-ALK Fusion Variants
Purpose: ALK rearrangement–positive lung cancers can be effectively treated with ALK inhibitors. However, the magnitude and… 
2012
2012
Neuroblastome, résistance in vivo à l'irinotecan et voie de signalisation ALK
Les neuroblastomes, meme de haut risque repondent bien a la chimiotherapie initiale mais deviendront frequemment resistants au… 
2012
2012
Reply to T. Komiya et al
Komiya et al raise an important point that many so-called targeted drugs in fact inhibit multiple related proteins. Crizotinib is… 
2011
2011
Abstract 1541: Secondary mutations in ALK and resistance to ALK kinase inhibitors
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Background: The anaplastic lymphoma kinase (ALK… 
2010
2010
ALK and resistance
A small proportion of non-small-cell lung cancers (between 2% and 7%) have a chromosomal translocation that results in the fusion… 
2008
2008
Genetics: ALK takes the rap
can be an inherited or a sporadic tumour but, unlike retinoblastoma, the genetics underlying neuro­ blastoma development have… 
2006
2006
Inhibition of the NPM-ALK Fusion Tyrosine Kinase in Hematopoietic Neoplasia by the Small Molecule Tyrosine Kinase Antagonist TAE684.
Anaplastic large cell lymphoma (ALCL) constitutes approximately 10–30 percent of childhood lymphomas and 3 percent of non-Hodgkin… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)