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NUDT1 wt Allele

Known as: MTH1, Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 wt Allele 
Human NUDT1 wild-type allele is located within 7p22 and is approximately 9 kb in length. This allele, which encodes 7,8-dihydro-8-oxoguanine… 
National Institutes of Health

Related topics

Related topics

4 relations
7p22Homo sapiensHydrolysis

Broader (1)

NUDT1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Birth of MTH1 as a therapeutic target for glioblastoma: MTH1 is indispensable for gliomatumorigenesis.
Malignant glioma is the most common primary tumor of the central nervous system. Chemotherapy and radiotherapy are the most… 
Highly Cited
2011
Highly Cited
2011
Abstract 1189: MiR-145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1
OBJECTIVE: MicroRNAs (miRNAs) are emerging as important modulators in cellular pathways and appear to play a key role in… 
2007
2007
MYH, OGG1, MTH1, and APC alterations involved in the colorectal tumorigenesis of Korean patients with multiple adenomas
This study was done to characterize base excision repair (BER) genes and adenomatous polyposis coli (APC) alterations in the… 
2007
2007
Analysis of the base excision repair genes MTH1, OGG1 and MUTYH in patients with squamous oral carcinomas.
Review
2005
Review
2005
Modulation of oxidative mutagenesis and carcinogenesis by polymorphic forms of human DNA repair enzymes.
Review
2004
Review
2004
ReviewThe Defense Mechanisms in Mammalian Cells against Oxidative Damage in Nucleic Acids and their Involvement in the Suppression of Mutagenesis and Cell Death
To counteract oxidative damage in nucleic acids, mammalian cells are equipped with several defense mechanisms. We herein review… 
Highly Cited
2003
Highly Cited
2003
Increase of human MTH1 and decrease of 8-hydroxydeoxyguanosine in leukocyte DNA by acute and chronic exercise in healthy male subjects.
2001
2001
Analysis of MTH1 gene function in mice with targeted mutagenesis.
1997
1997
Biochemical and physicochemical characterization of normal and variant forms of human MTH1 protein with antimutagenic activity.
Highly Cited
1995
Highly Cited
1995
Mouse MTH1 Protein with 8-Oxo-7,8-dihydro-2′-deoxyguanosine 5′-Triphosphatase Activity That Prevents Transversion Mutation
8-Oxo-7,8-dihydro-2′-deoxyguanosine 5′-triphosphate (8-oxo-dGTP) is formed in the nucleotide pool of a cell during normal… 
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