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NUDT1 wt Allele

Known as: MTH1, Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 wt Allele 
Human NUDT1 wild-type allele is located within 7p22 and is approximately 9 kb in length. This allele, which encodes 7,8-dihydro-8-oxoguanine… 
National Institutes of Health

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4 relations
7p22Homo sapiensHydrolysis

Broader (1)

NUDT1 gene

Papers overview

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2019
2019
Improved metabolic control using glucose monitoring systems leads to improvement in vibration perception thresholds in type 1 diabetes patients
Aims Few studies have examined how improved metabolic control might influence vibration perception thresholds (VPTs). The aim of… 
2011
2011
NDX-1 protein hydrolyzes 8-oxo-7, 8-dihydrodeoxyguanosine-5'-diphosphate to sanitize oxidized nucleotides and prevent oxidative stress in Caenorhabditis elegans.
8-oxo-dGTP is generated in the nucleotide pool by direct oxidation of dGTP or phosphorylation of 8-oxo-dGDP. It can be… 
2008
2008
OGG1, MYH and MTH1 gene variants identified in gastric cancer patients exhibiting both 8-hydroxy-2′-deoxyguanosine accumulation and low inflammatory cell infiltration in their gastric mucosa
Introduction 8-Hydroxy-2′-deoxyguanosine (8-OHdG) is one of the main DNA modifications produced by reactive oxygen species (ROS… 
2007
2007
Analysis of the base excision repair genes MTH1, OGG1 and MUTYH in patients with squamous oral carcinomas.
2006
2006
Recognition of nucleotide analogs containing the 7,8-dihydro-8-oxo structure by the human MTH1 protein.
The MTH1 protein catalyzes hydrolysis of oxidatively damaged purine nucleotides including 8-hydroxy-dGTP to the monophosphates… 
2006
2006
The GT to GC single nucleotide polymorphism at the beginning of an alternative exon 2C of human MTH1 gene confers an amino terminal extension that functions as a mitochondrial targeting signal
Human MTH1 protein hydrolyzes oxidized purine nucleotides 8-oxo-2′-deoxyguanosine triphosphate (8-oxo-dGTP), 2-OH-dATP or their… 
2003
2003
Inhibition of 8-oxo-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase (8-oxo-dGTPase) activity of the antimutagenic human MTH1 protein by nucleoside 5'-diphosphates.
2000
2000
Activity of the antimutagenic enzyme 8-oxo-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase (8-oxo-dGTPase) in cultured chinese hamster ovary cells: effects of cell cycle, proliferation rate…
1997
1997
Biochemical and physicochemical characterization of normal and variant forms of human MTH1 protein with antimutagenic activity.
Highly Cited
1995
Highly Cited
1995
Mouse MTH1 Protein with 8-Oxo-7,8-dihydro-2′-deoxyguanosine 5′-Triphosphatase Activity That Prevents Transversion Mutation
8-Oxo-7,8-dihydro-2′-deoxyguanosine 5′-triphosphate (8-oxo-dGTP) is formed in the nucleotide pool of a cell during normal… 
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