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NUDT1 wt Allele

Known as: MTH1, Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 wt Allele 
Human NUDT1 wild-type allele is located within 7p22 and is approximately 9 kb in length. This allele, which encodes 7,8-dihydro-8-oxoguanine… 
National Institutes of Health

Related topics

Related topics

4 relations
7p22Homo sapiensHydrolysis

Broader (1)

NUDT1 gene

Papers overview

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Highly Cited
2016
Highly Cited
2016
Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival.
Recent literature has claimed that inhibition of the enzyme MTH1 can eradicate cancer. MTH1 is one of the "housekeeping" enzymes… 
Highly Cited
2016
Highly Cited
2016
Validation and development of MTH1 inhibitors for treatment of cancer.
BACKGROUND Previously, we showed cancer cells rely on the MTH1 protein to prevent incorporation of otherwise deadly oxidised… 
Review
2014
Review
2014
Stereospecific targeting of MTH1 by (S)-crizotinib as anticancer strategy
Activated RAS GTPase signalling is a critical driver of oncogenic transformation and malignant disease. Cellular models of RAS… 
Highly Cited
2003
Highly Cited
2003
Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption.
Using Mth1 and Ogg1 knockout mice, we evaluated the roles of these enzymes to prevent tumorigenesis and the accumulation of 8… 
Highly Cited
2003
Highly Cited
2003
Grr1-dependent inactivation of Mth1 mediates glucose-induced dissociation of Rgt1 from HXT gene promoters.
In budding yeast, HXT genes encoding hexose permeases are induced by glucose via a mechanism in which the F box protein Grr1… 
Highly Cited
2001
Highly Cited
2001
Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP.
The human nucleotide pool sanitization enzyme, MTH1, hydrolyzes 2-hydroxy-dATP and 8-hydroxy-dATP in addition to 8-hydroxy-dGTP… 
Highly Cited
1999
Highly Cited
1999
Structural and functional predictors of regional peak pressures under the foot during walking.
Highly Cited
1999
Highly Cited
1999
The Oxidized Forms of dATP Are Substrates for the Human MutT Homologue, the hMTH1 Protein*
The possibility that Escherichia coliMutT and human MTH1 (hMTH1) hydrolyze oxidized DNA precursors other than 8-hydroxy-dGTP (8… 
Highly Cited
1999
Highly Cited
1999
Std1 and Mth1 Proteins Interact with the Glucose Sensors To Control Glucose-Regulated Gene Expression in Saccharomyces cerevisiae
ABSTRACT The Std1 protein modulates the expression of glucose-regulated genes, but its exact molecular role in this process is… 
Highly Cited
1995
Highly Cited
1995
Mouse MTH1 Protein with 8-Oxo-7,8-dihydro-2′-deoxyguanosine 5′-Triphosphatase Activity That Prevents Transversion Mutation
8-Oxo-7,8-dihydro-2′-deoxyguanosine 5′-triphosphate (8-oxo-dGTP) is formed in the nucleotide pool of a cell during normal… 
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