NU2058

Known as: O(6)-cyclohexylmethylguanine 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2000-2014
01220002014

Papers overview

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2014
2014
Evaluation of the effects of purine C-8 substitution within a series of CDK1/2-selective O(6)-cyclohexylmethylguanine derivatives… (More)
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2010
2010
Background:Cellular proliferation, driven by cyclin-dependent kinases (CDKs) and their cyclin partners, is deregulated in cancer… (More)
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2009
2009
O(6)-Cyclohexylmethylguanine (NU2058) was developed as an inhibitor of CDK2 and was previously shown to potentiate cisplatin… (More)
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2007
2007
Antiandrogens are initially effective in controlling prostate cancer (CaP), the second most common cancer in men, but resistance… (More)
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2005
2005
Pharmacological inhibitors of cyclin-dependent kinase (CDK)2 are currently in preclinical and clinical development. The purpose… (More)
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2005
2005
By screening 1,990 compounds from the National Cancer Institute diversity set library against human topoisomerase IIalpha, we… (More)
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2004
2004
The adenosine 5'-triphosphate (ATP) competitive cyclin-dependent kinase inhibitor O(6)-cyclohexylmethylguanine (NU2058, 1) has… (More)
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2004
2004
Cyclin-dependent protein kinases play important roles in cell cycle progression and are attractive targets for the design of anti… (More)
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2002
2002
O(6)-substituted guanines are adenosine 5'-triphosphate (ATP) competitive inhibitors of CDK1/cyclin B1 and CDK2/cyclin A, the O(6… (More)
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2000
2000
Substituted guanines and pyrimidines were tested as inhibitors of cyclin B1/CDK1 and cyclin A3/CDK2 and soaked into crystals of… (More)
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