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NU2058

Known as: O(6)-cyclohexylmethylguanine 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Guanine
analogs & derivatives

Papers overview

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2013
2013
Effect of NU2058 on growth and proliferation of HCT-8 cell
【Objective】 To investigate the influence of NU2058 on the growth and proliferation of col- orectal cancer cells in vitro. 【Method… 
2009
2009
The kinase inhibitor O 6-cyclohexylmethylguanine ( NU 2058 ) potentiates the cytotoxicity of cisplatin by mechanisms that are independent of its effect upon CDK 2
O-Cyclohexylmethylguanine (NU2058) was developed as an inhibitor of CDK2 and was previously shown to potentiate cisplatin… 
2005
2005
Substituted purine analogues define a novel structural class of catalytic topoisomerase II inhibitors.
By screening 1,990 compounds from the National Cancer Institute diversity set library against human topoisomerase IIalpha, we… 
2004
2004
The Development of a CDK2-Docking Site Peptide that Inhibits p53 and Sensitizes Cells to Death
Cyclin-dependent protein kinases play important roles in cell cycle progression and are attractive targets for the design of anti… 
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