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NU 6027

Known as: NU-6027, NU6027 
 
National Institutes of Health

Papers overview

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2019
2019
NU-6027 Inhibits Growth of Mycobacterium tuberculosis by Targeting Protein Kinase D and Protein Kinase G
Tuberculosis (TB) is a global health concern, and this situation has further worsened due to the emergence of drug-resistant… Expand
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2019
2019
Effects of the transient receptor potential cation channel 5 (TRPC5) inhibitor NU6027 on hippocampal neuronal death after traumatic brain injury
 
2018
2018
Contribution of Zinc-Dependent Delayed Calcium Influx via TRPC5 in Oxidative Neuronal Death and its Prevention by Novel TRPC Antagonist
Oxidative stress is a key mediator of neuronal death in acute brain injuries, such as epilepsy, trauma, and stroke. Although it… Expand
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2016
2016
Synthesis and Biological Evaluation of N2‐Substituted 2,4‐Diamino‐6‐cyclohexylmethoxy‐5‐nitrosopyrimidines and Related 5‐Cyano‐NNO‐azoxy Derivatives as Cyclin‐Dependent Kinase 2 (CDK2) Inhibitors
The potent and selective cyclin‐dependent kinase 2 (CDK2) inhibitor NU6027 (6‐cyclohexylmethoxy‐5‐nitroso‐2,4‐diaminopyrimidine… Expand
2016
2016
This is the author's final version of the contribution published as: Synthesis and biological evaluation of new N2-substituted 2,4-diamino-6- cyclohexylmethoxy-5-nitrosopyrimidines and related 5…
The potent and selective Cyclin-Dependent Kinase 2 (CDK2) inhibitor NU6027 (6-cyclohexylmethoxy-5nitroso-2,4-diaminopyrimidine… Expand
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2014
2014
Trovafloxacin Enhances Lipopolysaccharide-Stimulated Production of Tumor Necrosis Factor-α by Macrophages: Role of the DNA Damage Response
Trovafloxacin (TVX) is a drug that has caused idiosyncratic, drug-induced liver injury (IDILI) in humans. In a murine model of… Expand
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2013
2013
6-Cyclohexylmethoxy-5-(cyano-NNO-azoxy)pyrimidine-4-amine: a new scaffold endowed with potent CDK2 inhibitory activity.
Substitution of the cyano-NNO-azoxy moiety (NC-N=(O)N-) for the nitroso group in NU6027, a potent and selective CDK2 inhibitor… Expand
Highly Cited
2011
Highly Cited
2011
Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines
Background:The ataxia telangiectasia mutated and Rad3-related kinase (ATR) has a key role in the signalling of stalled… Expand
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2003
2003
4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2.
The cyclin dependent kinase (cdk) inhibitor NU6027, 4-cyclohexylmethoxy-5-nitroso-pyrimidine-2,6-diamine (IC(50) vs cdk1/cyclinB1… Expand
Highly Cited
2000
Highly Cited
2000
Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles.
Substituted guanines and pyrimidines were tested as inhibitors of cyclin B1/CDK1 and cyclin A3/CDK2 and soaked into crystals of… Expand
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