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NU 6027
Known as:
NU-6027
, NU6027
National Institutes of Health
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Papers overview
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2019
2019
NU-6027 Inhibits Growth of Mycobacterium tuberculosis by Targeting Protein Kinase D and Protein Kinase G
Saqib Kidwai
,
Rania Bouzeyen
,
+12 authors
Ramandeep Singh
Antimicrobial Agents and Chemotherapy
2019
Corpus ID: 195844608
Tuberculosis (TB) is a global health concern, and this situation has further worsened due to the emergence of drug-resistant…
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2019
2019
Effects of the transient receptor potential cation channel 5 (TRPC5) inhibitor NU6027 on hippocampal neuronal death after traumatic brain injury
Min Kyu Park
,
Bo Young Choi
,
+6 authors
S. Suh
IBRO Reports
2019
Corpus ID: 203811868
2018
2018
Contribution of Zinc-Dependent Delayed Calcium Influx via TRPC5 in Oxidative Neuronal Death and its Prevention by Novel TRPC Antagonist
Sang eun Park
,
Ji Hoon Song
,
+16 authors
J. Hwang
Molecular Neurobiology
2018
Corpus ID: 51872617
Oxidative stress is a key mediator of neuronal death in acute brain injuries, such as epilepsy, trauma, and stroke. Although it…
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2016
2016
Synthesis and Biological Evaluation of N2‐Substituted 2,4‐Diamino‐6‐cyclohexylmethoxy‐5‐nitrosopyrimidines and Related 5‐Cyano‐NNO‐azoxy Derivatives as Cyclin‐Dependent Kinase 2 (CDK2) Inhibitors
Daniel K. Cortese
,
K. Chegaev
,
+4 authors
R. Fruttero
ChemMedChem
2016
Corpus ID: 5007036
The potent and selective cyclin‐dependent kinase 2 (CDK2) inhibitor NU6027 (6‐cyclohexylmethoxy‐5‐nitroso‐2,4‐diaminopyrimidine…
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2016
2016
This is the author's final version of the contribution published as: Synthesis and biological evaluation of new N2-substituted 2,4-diamino-6- cyclohexylmethoxy-5-nitrosopyrimidines and related 5…
Daniel K. Cortese
,
K. Chegaev
,
C. Cano
2016
Corpus ID: 51856592
The potent and selective Cyclin-Dependent Kinase 2 (CDK2) inhibitor NU6027 (6-cyclohexylmethoxy-5nitroso-2,4-diaminopyrimidine…
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2014
2014
Trovafloxacin Enhances Lipopolysaccharide-Stimulated Production of Tumor Necrosis Factor-α by Macrophages: Role of the DNA Damage Response
K. Poulsen
,
J. Olivero-Verbel
,
Kevin M. Beggs
,
P. Ganey
,
R. Roth
The Journal of Pharmacology and Experimental…
2014
Corpus ID: 3014160
Trovafloxacin (TVX) is a drug that has caused idiosyncratic, drug-induced liver injury (IDILI) in humans. In a murine model of…
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2013
2013
6-Cyclohexylmethoxy-5-(cyano-NNO-azoxy)pyrimidine-4-amine: a new scaffold endowed with potent CDK2 inhibitory activity.
D. Boschi
,
P. Tosco
,
+5 authors
A. Gasco
European journal of medicinal chemistry
2013
Corpus ID: 27459550
Highly Cited
2011
Highly Cited
2011
Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines
A. Peasland
,
Lz Wang
,
+8 authors
N. Curtin
British Journal of Cancer
2011
Corpus ID: 14728077
Background:The ataxia telangiectasia mutated and Rad3-related kinase (ATR) has a key role in the signalling of stalled…
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2003
2003
4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2.
Veronique Mesguiche
,
Rachel J Parsons
,
+14 authors
I. Hardcastle
Bioorganic & medicinal chemistry letters
2003
Corpus ID: 23954662
Highly Cited
2000
Highly Cited
2000
Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles.
C. E. Arris
,
F. Boyle
,
+15 authors
W. Yu
Journal of medicinal chemistry
2000
Corpus ID: 23697892
Substituted guanines and pyrimidines were tested as inhibitors of cyclin B1/CDK1 and cyclin A3/CDK2 and soaked into crystals of…
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