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Biodistribution of 89Zr‐trastuzumab and PET Imaging of HER2‐Positive Lesions in Patients With Metastatic Breast Cancer
PET scanning after administration of the monoclonal antibody zirconium‐89 at appropriate doses allows visualization and quantification of uptake in HER2‐positive lesions in patients with metastatic breast cancer. Expand
The sulfhydryl containing compounds WR-2721 and glutathione as radio- and chemoprotective agents. A review, indications for use and prospects
Two sulfhydryl compounds are reviewed, namely the agent WR-2721 (amifostine), a compound recently registered for use in human in many countries, and the natural occurring compound glutathione (GSH), which is not registered as a chemoprotective agent. Expand
Genetic factors influencing Pyrimidine-antagonist chemotherapy
In this review, proteins relevant for the efficacy and toxicity of pyrimidine antagonists will be summarised, and the role of germline polymorphisms, tumour-specific somatic mutations and protein expression levels in the metabolic pathways and clinical pharmacology of these drugs are described. Expand
Diminished expression of multidrug resistance-associated protein 1 (MRP1) in bronchial epithelium of COPD patients
Findings indicate that diminished MRP1 expression in normal bronchial epithelium is associated with COPD, and the exact role in COPD pathogenesis is to be revealed by further functional studies. Expand
Venlafaxine versus clonidine for the treatment of hot flashes in breast cancer patients: a double-blind, randomized cross-over study
Venlafaxine and clonidine are equally, but moderately effective in HF reduction, and side effects are the main reason for drug discontinuation, occurring more often with venlafxine. Expand
Testicular germ cell tumours: the paradigm of chemo-sensitive solid tumours.
Testicular germ cell tumours (TGCTs) are the most frequent solid malignant tumour in men 20-40 years of age and the most frequent cause of death from solid tumours in this age group. Up to 50% of theExpand
Clinical Evaluation of M 30 and M 65 ELISA Cell Death Assays as Circulating Biomarkers in a Drug-Sensitive Tumor , Testicular Cancer 1
Circulating full-length and caspase-cleaved cytokeratin 18 (CK18) are considered biomarkers of chemotherapyinduced cell death measured using a combination of the M30 and M65 ELISAs. M30 measuresExpand
Preclinical characterisation of 111In‐DTPA‐trastuzumab
111In‐DTPA‐trastuzumab appears suitable for clinical use and can be efficiently radiolabelled with 111In with high labelling yields and high stability. Expand
Influence of functional polymorphisms of the MDR1 gene on vincristine pharmacokinetics in childhood acute lymphoblastic Leukemia
Our objective was to investigate the effect of single nucleotide polymorphisms (SNPs) in the P‐glycoprotein MDR1 gene on vincristine pharmacokinetics and side effects in childhood acute lymphoblasticExpand
Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin
The plasma concentrations reached in the patients were insufficient to induce significant growth inhibition in vitro, and the maximum tolerated dose (MTD) has not been reached, but further escalation seems possible and is warranted to achieve potentially effective drug levels. Expand