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NU 1025

Known as: NU1025 
National Institutes of Health

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Quinazolines

Papers overview

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2015
2015
TACC3 in personalized medicine
Cells are constantly exposed to endogenous and exogenous DNA damage events. In order to confront DNA damage and to maintain… 
2014
2014
Interactions Between Ataxia Telangiectasia Mutated Kinase Inhibition, Poly(ADP-ribose) Polymerase-1 Inhibition and BRCA1 Status in Breast Cancer Cells
Background: Cells harboring BRCA1/BRCA2 mutations are hypersensitive to inhibition of poly(ADP-ribose) polymerase-1 (PARP-1). We… 
2013
2013
Repair of DNA Strand Breaks in a Minichromosome In Vivo: Kinetics, Modeling, and Effects of Inhibitors
To obtain an overall picture of the repair of DNA single and double strand breaks in a defined region of chromatin in vivo, we… 
2012
2012
Rotenone-Induced Death of RGC-5 Cells is Caspase Independent, Involves the JNK and p38 Pathways and is Attenuated by Specific Green Tea Flavonoids
The aim of the present studies was to characterise cell death following inhibition of mitochondrial complex I with rotenone in a… 
2008
2008
[Neuroprotective effect of epigallocatechin gallate on oxidative-stress-injured retinal cells].
OBJECTIVE To investigate the neuroprotective effect of epigallocatechin gallate(EGCG), the main extract from green tea, on the… 
2008
2008
Exploiting the Achilles heel of cancer: the therapeutic potential of poly(ADP-ribose) polymerase inhibitors in BRCA2-defective cancer.
Poly(ADP-ribose) polymerase-1 (PARP-1) facilitates DNA single-strand break-base excision repair to maintain genomic stability… 
Highly Cited
2002
Highly Cited
2002
Combined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site.
Temozolomide (TZM) is a DNA-methylating agent that has recently been introduced into various clinical trials for treatment of… 
2002
2002
Apoptotic and genotoxic effects of a methyl sulfonate ester that selectively generates N3-methyladenine and poly(ADP-ribose) polymerase inhibitors in normal peripheral blood lymphocytes
Abstract. Selective N3-adenine methylation represents a novel strategy for tumors with a phenotype of poor responsiveness to a… 
1995
1995
Biological effects of novel poly (adenosine diphosphate ribose) polymerase inhibitors
Poly(ADP-ribose) polymerase (PADPRP) is a nuclear enzyme with a well documented role in DNA repair. Inhibitors of P ADPRP, (e.g… 
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