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NT5C2 gene

Known as: 5'-Nucleotidase, Cytosolic II Gene, cN-II, NUCLEOTIDASE, 5-PRIME, TYPE B 
This gene plays a role in purine metabolism.
National Institutes of Health

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Related topics

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Drug Metabolism InductionHydrolysisNT5C2 protein, humanNucleotide Metabolism

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NT5C2 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Circular RNA circ-NT5C2 acts as a potential novel biomarker for prognosis of osteosarcoma.
OBJECTIVE Recent evidence suggests that circular RNAs (circRNAs) play important roles in multiple diseases, including cancer… 
2018
2018
Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation
Activating mutations in NT5C2, a gene encoding cytosolic purine 5′-nucleotidase (cN-II), confer chemoresistance in relapsed acute… 
2017
2017
Aberrant splicing in B-cell acute lymphoblastic leukemia
Background Mutations in splicing factor (SF) genes cause myelodysplastic syndromes and chronic lymphocytic leukemia (CLL). While… 
2015
2015
Role of pharmacogenetic in ribavirin outcome prediction and pharmacokinetics in an Italian cohort of HCV-1 and 4 patients.
2015
2015
Mutant PRPS1: a new therapeutic target in relapsed acute lymphoblastic leukemia
A new study identifies recurrent mutations in the purine biosynthesis gene phosphoribosyl pyrophosphate synthetase 1 (PRPS1) in… 
2015
2015
IMP-GMP specific cytosolic 5'-nucleotidase regulates nucleotide pool and prodrug metabolism.
2008
2008
Differential Allelic Expression in Leukoblast from Patients with Acute Myeloid Leukemia Suggests Genetic Regulation of CDA, DCK, NT5C2, NT5C3, and TP53
mRNA expression levels of certain genes have shown predictive value for the outcome of cytarabine-treated AML-patients. We… 
2006
2006
QTL Mapping for Developmental Behavior of GMP Content in Wheat
Glutenin macropolymer(GMP) content is a key factor influencing wheat processing quality,which is determined by quantitative trait… 
Highly Cited
2003
Highly Cited
2003
Cytosolic and mitochondrial deoxyribonucleotidases: activity with substrate analogs, inhibitors and implications for therapy.
1969
1969
Nucleoside antibiotics. IV. Metabolic fate of adenosine and cordycepin by Cordyceps militaris during cordycepin biosynthesis.
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