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NSC606985

 
National Institutes of Health

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2 relations

Broader (1)

Camptothecin
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Dual action of NSC606985 on cell growth and apoptosis mediated through PKCδ in prostatic cancer cells
Chemotherapy is a vital therapeutic strategy for castration-resistant prostate cancer (CRPC). We have previously shown that… Expand
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2010
2010
Downregulation of ANP32B, a novel substrate of caspase-3, enhances caspase-3 activation and apoptosis induction in myeloid leukemic cells.
The acidic leucine-rich nuclear phosphoprotein 32 (ANP32)B has been reported to regulate gene expression by acting as a histone… Expand
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2009
2009
NSC606985 induces apoptosis, exerts synergistic effects with cisplatin, and inhibits hypoxia-stabilized HIF-1alpha protein in human ovarian cancer cells.
The camptothecins, which target the intranuclear enzyme topoisomerase I, have advanced to the forefront of several areas of… Expand
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2009
2009
Protein kinase C-delta mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction.
We reported previously that NSC606985, a camptothecin analogue, induces apoptosis of acute myeloid leukemia (AML) cells through… Expand
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2009
2009
NDRG1 is down-regulated in the early apoptotic event induced by camptothecin analogs: the potential role in proteolytic activation of PKC delta and apoptosis.
We previously reported that NSC606985, a new camptothecin analog, induces apoptosis of acute myeloid leukemic cells, which is… Expand
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2008
2008
NSC606985, a novel camptothecin analog, induces apoptosis and growth arrest in prostate tumor cells
PurposeProstate cancer is a major cause of cancer mortality in American males. Once prostate cancer has metastasized, there is… Expand
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2008
2008
Phosphorylation of β-actin by protein kinase C-delta in camptothecin analog-induced leukemic cell apoptosis
AbstractAim:This study was conducted to reveal new proteins involved in acute myeloid leukemia (AML) cell apoptosis.Methods:Using… Expand
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2007
2007
Subcellular proteome analysis of camptothecin analogue NSC606985-treated acute myeloid leukemic cells.
We reported previously that NSC606985, a camptothecin analogue, induces apoptosis of acute myeloid leukemia (AML) cells through… Expand
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2007
2007
Therapeutic efficacy of NSC606985, a novel camptothecin analog, in a mouse model of acute promyelocytic leukemia.
Nanomolar concentrations of NSC606985, a novel camptothecin (CPT) analog, effectively induces apoptosis in vitro in acute myeloid… Expand
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2005
2005
Nanomolar concentration of NSC606985, a camptothecin analog, induces leukemic-cell apoptosis through protein kinase Cdelta-dependent mechanisms.
As a promising new class of anticancer drugs, camptothecins have advanced to the forefront of several areas of therapeutic and… Expand
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