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NSC606985

 
National Institutes of Health

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Broader (1)

Camptothecin
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Downregulation of ANP32B, a novel substrate of caspase-3, enhances caspase-3 activation and apoptosis induction in myeloid leukemic cells.
The acidic leucine-rich nuclear phosphoprotein 32 (ANP32)B has been reported to regulate gene expression by acting as a histone… Expand
2009
2009
NSC606985 induces apoptosis, exerts synergistic effects with cisplatin, and inhibits hypoxia-stabilized HIF-1alpha protein in human ovarian cancer cells.
The camptothecins, which target the intranuclear enzyme topoisomerase I, have advanced to the forefront of several areas of… Expand
2009
2009
Protein kinase C-delta mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction.
We reported previously that NSC606985, a camptothecin analogue, induces apoptosis of acute myeloid leukemia (AML) cells through… Expand
2009
2009
NDRG1 is down‐regulated in the early apoptotic event induced by camptothecin analogs: The potential role in proteolytic activation of PKCδ and apoptosis
We previously reported that NSC606985, a new camptothecin analog, induces apoptosis of acute myeloid leukemic cells, which is… Expand
2009
2009
PU.1, a novel caspase-3 substrate, partially contributes to chemotherapeutic agents-induced apoptosis in leukemic cells.
PU.1 is one of key regulators of hematopoietic cell development, a tightly-regulated lineage-specific process. Here we provide… Expand
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2008
2008
NSC606985, a novel camptothecin analog, induces apoptosis and growth arrest in prostate tumor cells
PurposeProstate cancer is a major cause of cancer mortality in American males. Once prostate cancer has metastasized, there is… Expand
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2008
2008
Phosphorylation of β-actin by protein kinase C-delta in camptothecin analog-induced leukemic cell apoptosis
AbstractAim:This study was conducted to reveal new proteins involved in acute myeloid leukemia (AML) cell apoptosis.Methods:Using… Expand
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2007
2007
Subcellular proteome analysis of camptothecin analogue NSC606985-treated acute myeloid leukemic cells.
We reported previously that NSC606985, a camptothecin analogue, induces apoptosis of acute myeloid leukemia (AML) cells through… Expand
2007
2007
Therapeutic efficacy of NSC606985, a novel camptothecin analog, in a mouse model of acute promyelocytic leukemia.
Nanomolar concentrations of NSC606985, a novel camptothecin (CPT) analog, effectively induces apoptosis in vitro in acute myeloid… Expand
Highly Cited
2005
Highly Cited
2005
Nanomolar concentration of NSC606985, a camptothecin analog, induces leukemic-cell apoptosis through protein kinase Cdelta-dependent mechanisms.
As a promising new class of anticancer drugs, camptothecins have advanced to the forefront of several areas of therapeutic and… Expand
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