NSC606985
National Institutes of Health
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We previously reported that NSC606985, a new camptothecin analog, induces apoptosis of acute myeloid leukemic cells, which is…
Background The precise regulation and maintenance of balance between cell proliferation, differentiation and death in metazoan…
Dihydrofolate reductase (DHFR) is a key enzyme for the synthesis of thymidylate, and therefore, of DNA. By applying subcellular…
As a promising new class of anticancer drugs, camptothecins have advanced to the forefront of several areas of therapeutic and…