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NSC 694501

Known as: NSC-694501, NSC694501 
National Institutes of Health

Papers overview

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2006
2006
Time-dependent cytotoxicity induced by SJG-136 (NSC 694501): influence of the rate of interstrand cross-link formation on DNA damage signaling
SJG-136 is a new pyrrolobenzodiazepine dimer inducing time-dependent cytotoxicity. HCT 116 cells were exposed to 50 nmol/L of SJG… 
2006
2006
LC-MS/MS assay and dog pharmacokinetics of the dimeric pyrrolobenzodiazepine SJG-136 (NSC 694501).
2005
2005
Direct liquid chromatography determination of the reactive imine SJG-136 (NSC 694501).
2004
2004
Preliminary pharmacokinetic and bioanalytical studies of SJG-136 (NSC 694501), a sequence-selective pyrrolobenzodiazepine dimer DNA-cross-linking agent
SJG-136 is a synthetic pyrrolobenzodiazepine (PBD) dimer in which two DNA-alkylating subunits are linked through an inert… 
2004
2004
559 The novel DNA cross-linking agent SJG-136 (NSC 694501) exhibits potent, selective and p53-independent cytotoxicity in human chronic lymphocytic leukaemia cells
2002
2002
Efficacy evaluations of SJG-136 (NSC 694501), a novel pyrrolobenzodiazepine dimer with broad spectrum antitumor activity
2002
2002
In vitro antitumor activity and in vivo DNA interstrand crosslinking by the novel pyrrolobenzodiazepine dimer SJG-136 (NSC 694501)
2002
2002
In vitro activity and in vivo DNA interstrand crosslinking by the novel pyrrolobenzodiazepine dimer SJG-136 (NSC 694501).
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