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NSC-134754

National Institutes of Health

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Isoquinolines

Papers overview

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2010
2010
Effect of the HIF Pathway Inhibitor NSC-134754 on Glucose Metabolism
PC3LN5 cells with 7.5μM NSC134754 for 24h in hypoxia; effects on glucose transport, glucose metabolism and lactate levels. A… 
2010
2010
Abstract 2282: Inhibition of vasculogenesis, but not angiogenesis, reduces tumor recurrence following irradiation
Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC Tumor blood vessels can derive from two sources… 
2009
2009
Response of Orthotopic PC 3 Prostate Tumors to the HIF Pathway Inhibitor NSC-134754 Assessed by Diffusion Weighted MRI and Immunohistochemistry
Introduction The hypoxia-inducible factor (HIF) pathway is a key regulator in tumor cell adaptation to the hypoxic… 
2008
2008
Evaluating Acute Response to the Novel HIF Inhibitor NSC-134754 in an Orthotopic Prostate Tumour Model by MRI
Introduction Tumour hypoxia and angiogenesis are classic hallmarks of the tumour microenvironment. Tumour cells adapt to hypoxic… 
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