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NR4A1 gene

Known as: NR4A1, NP10, NGFIB 
This gene is involved in the induction of apoptosis. It also plays a role in regulation of transcription.
National Institutes of Health

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Related topics

14 relations
Biologic DevelopmentCell Differentiation processCell ProliferationHomeostasis

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NR4A1 wt Allele

Papers overview

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Highly Cited
2005
Highly Cited
2005
The expression of fascin, an actin-bundling motility protein, correlates with hormone receptor-negative breast cancer and a more aggressive clinical course.
The invasion and metastasis of tumor cells is a major cause of mortality in cancer patients. In the current study, we… 
Highly Cited
2004
Highly Cited
2004
The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production.
Aldosterone biosynthesis in the zona glomerulosa of the adrenal cortex is regulated by transcription of CYP11B2 (encoding… 
Highly Cited
2003
Highly Cited
2003
A Thyroid Hormone Receptor α Gene Mutation (P398H) Is Associated with Visceral Adiposity and Impaired Catecholamine-stimulated Lipolysis in Mice*
Thyroid hormone has profound effects on metabolic homeostasis, regulating both lipogenesis and lipolysis, primarily by modulating… 
Highly Cited
2002
Highly Cited
2002
Retardation of post‐natal development caused by a negatively acting thyroid hormone receptor α1
Most patients with the syndrome resistance to thyroid hormone (RTH) express a mutant thyroid hormone receptor β (TRβ) with… 
Highly Cited
2001
Highly Cited
2001
Akt phosphorylates and regulates the orphan nuclear receptor Nur77
The immediate early gene NUR77 (also called NGFI-B) is required for T cell antigen receptor-mediated cell death and is induced to… 
Highly Cited
2000
Highly Cited
2000
Bone homeostasis in growth hormone receptor-null mice is restored by IGF-I but independent of Stat5.
Growth hormone (GH) regulates both bone growth and remodeling, but it is unclear whether these actions are mediated directly by… 
Highly Cited
1999
Highly Cited
1999
Tip60 Is a Nuclear Hormone Receptor Coactivator*
The androgen receptor (AR) is a member of the nuclear hormone receptor superfamily. Recent work in this field has been focused… 
Highly Cited
1995
Highly Cited
1995
Transcription factor TFIIB and the vitamin D receptor cooperatively activate ligand-dependent transcription.
The active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], regulates gene transcription through binding to the… 
Highly Cited
1994
Highly Cited
1994
Genetic analysis of 29 kindreds with generalized and pituitary resistance to thyroid hormone. Identification of thirteen novel mutations in the thyroid hormone receptor beta gene.
Resistance to thyroid hormone (RTH), with elevated serum free thyroid hormones and nonsuppressed thyrotropin levels, is either… 
Review
1980
Review
1980
Dynamics of steroid hormone receptor action.
The steroid hormones-estrogens, progestins, androgens, glucocorticoids, and mineralocorticoids-are chemically quite simple… 
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