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NR3C1 gene

Known as: NUCLEAR RECEPTOR SUBFAMILY 3, GROUP C, MEMBER 1, GRL, GR 
This gene is involved in ligand-activated transcriptional regulation and mutations in the gene are associated with glucocorticoid resistance.
National Institutes of Health

Related topics

Related topics

16 relations
Biologic DevelopmentCell Differentiation processCell ProliferationGlucocorticoid Receptor

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NR3C1 wt Allele

Papers overview

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Highly Cited
2010
Highly Cited
2010
Comparative determination of some phytohormones in wild-type and genetically modified plants by gas chromatography-mass spectrometry and high-performance liquid chromatography-tandem mass…
Highly Cited
2005
Highly Cited
2005
Repression of Interleukin-5 Transcription by the Glucocorticoid Receptor Targets GATA3 Signaling and Involves Histone Deacetylase Recruitment*
Glucocorticoids are the mainstay of asthma therapy and mediate the repression of a number of cytokine genes, such as Interleukin… 
Highly Cited
2001
Highly Cited
2001
GRKO mice express an aberrant dexamethasone-binding glucocorticoid receptor, but are profoundly glucocorticoid resistant
Highly Cited
1999
Highly Cited
1999
Interdomain Signaling in a Two-domain Fragment of the Human Glucocorticoid Receptor*
Studies of individual domains or subdomains of the proteins making up the nuclear receptor family have stressed their modular… 
Highly Cited
1999
Highly Cited
1999
Receptor Interacting Protein RIP140 Inhibits Both Positive and Negative Gene Regulation by Glucocorticoids*
Recent development in the field of gene regulation by nuclear receptors (NRs) have identified a role for cofactors in… 
Highly Cited
1997
Highly Cited
1997
Mechanism of interaction between the glucocorticoid receptor and Stat5: role of DNA-binding.
Highly Cited
1996
Highly Cited
1996
Candidate gene approach of familial morbid obesity: linkage analysis of the glucocorticoid receptor gene.
BACKGROUND Morbid obesity is a multifactorial disease, with a strong but almost unknown genetic component. Familial linkage… 
Highly Cited
1993
Highly Cited
1993
Killing of immature CD4+CD8+ thymocytes in vivo by anti‐CD3 or 5′‐(N‐ethyl)‐carboxamido‐adenosine is blocked by glucocorticoid receptor antagonist RU‐486
Negative selection in thymus occurs by apoptosis in CD4+CD81 cells. These immature thymocytes are readily killed, both in vitro… 
Highly Cited
1987
Highly Cited
1987
Intracellular localization of the glucocorticoid receptor: evidence for cytoplasmic and nuclear localization.
Using a monospecific, monoclonal antibody against the glucocorticoid receptor (GR), an immunocytochemical study was performed to… 
Highly Cited
1984
Highly Cited
1984
Monoclonal antibodies against the rat liver glucocorticoid receptor.
Splenic cells from one BALB/c mouse and one C57/BL mouse, immunized with purified rat liver glucocorticoid receptor (GR), were… 
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