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NR3C1 gene

Known as: NUCLEAR RECEPTOR SUBFAMILY 3, GROUP C, MEMBER 1, GRL, GR 
This gene is involved in ligand-activated transcriptional regulation and mutations in the gene are associated with glucocorticoid resistance.
National Institutes of Health

Related topics

Related topics

16 relations
Biologic DevelopmentCell Differentiation processCell ProliferationGlucocorticoid Receptor

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NR3C1 wt Allele

Papers overview

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Highly Cited
2014
Highly Cited
2014
Glucocorticoid Receptor Function Regulated by Coordinated Action of the Hsp90 and Hsp70 Chaperone Cycles
Highly Cited
2005
Highly Cited
2005
Structure of the glucocorticoid receptor (NR3C1) gene 5' untranslated region: identification, and tissue distribution of multiple new human exon 1.
The 5' untranslated region (UTR) of the glucocorticoid receptor (GR) plays a key role in determining tissue-specific expression… 
Highly Cited
2005
Highly Cited
2005
Mice with Genetically Altered Glucocorticoid Receptor Expression Show Altered Sensitivity for Stress-Induced Depressive Reactions
Altered glucocorticoid receptor (GR) signaling is a postulated mechanism for the pathogenesis of major depression. To mimic the… 
Highly Cited
2005
Highly Cited
2005
Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior.
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is a hallmark of major depressive disorder. A number of studies… 
Highly Cited
2004
Highly Cited
2004
Common polymorphisms in the glucocorticoid receptor gene are associated with adrenocortical responses to psychosocial stress.
Chronic dysregulation of hypothalamus-pituitary-adrenal axis activity is related to several stress-related disorders. Evidence… 
Highly Cited
2004
Highly Cited
2004
Rapid Glucocorticoid Receptor Exchange at a Promoter Is Coupled to Transcription and Regulated by Chaperones and Proteasomes
ABSTRACT Exchange of the glucocorticoid receptor (GR) at promoter target sites provides the only known system in which… 
Highly Cited
1997
Highly Cited
1997
Pancreatic beta cells are important targets for the diabetogenic effects of glucocorticoids.
Abnormalities contributing to the pathogenesis of non-insulin-dependent diabetes mellitus include impaired beta cell function… 
Highly Cited
1996
Highly Cited
1996
Distribution of glucocorticoid receptor immunoreactivity and mRNA in the rat brain: an immunohistochemical and in situ hybridization study
Highly Cited
1996
Highly Cited
1996
Visualization of glucocorticoid receptor translocation and intranuclear organization in living cells with a green fluorescent protein chimera.
A highly fluorescent mutant form of the green fluorescent protein (GFP) has been fused to the rat glucocorticoid receptor (GR… 
Highly Cited
1994
Highly Cited
1994
A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP‐1.
Steroid receptors activate and repress genes. An important class of genes that they repress is controlled by the transcription… 
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