• Publications
  • Influence
The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline.
TLDR
This guideline recommends that all patients with primary aldosteronism undergo adrenal computed tomography as the initial study in subtype testing and to exclude adrenocortical carcinoma and advises that an experienced radiologist should establish/exclude unilateral primary aldehydes using bilateral adrenal venous sampling.
Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guideline.
TLDR
The Task Force developed clinical practice guidelines for the diagnosis and treatment of patients with primary aldosteronism and recommended that patients with bilateral adrenal hyperplasia, or those unsuitable for surgery, optimally be treated medically by mineralocorticoid receptor antagonists.
Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated.
TLDR
The presence of the enzyme 11 beta-hydroxy-steroid dehydrogenase, which converts cortisol and corticosterone, but not aldosterone, to their 11-keto analogs, means that these analogs cannot bind to mineralocorticoid receptors.
Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues.
TLDR
To yield biologically active products, precursors commonly undergo a series of highly organized posttranslational events, including selective proteolytic cleavage and other enzymatic modifications which take place within specific membrane-bounded compartments.
Glucocorticoid and mineralocorticoid receptors: biology and clinical relevance.
  • J. Funder
  • Biology, Medicine
    Annual review of medicine
  • 1997
TLDR
Physiological roles for aldosterone and glucocorticoid membrane receptors, and for the recently described nuclear receptors for 11-ketosteroids in 11 beta-hydroxysteroid dehydro-genase-protected epithelia, remain to be established.
Dehydroepiandrosterone increases endothelial cell proliferation in vitro and improves endothelial function in vivo by mechanisms independent of androgen and estrogen receptors.
TLDR
DHEA increases EC proliferation in vitro by mechanism(s) independently of either androgen receptor or estrogen receptor and in vivo enhances large and small vessel EC function in postmenopausal women.
Mineralocorticoid Receptors: Distribution and Activation
TLDR
Cortisol changes from an MR antagonist to an MR agonist when intracellular redox state is changed—by inhibition of 11β HSD2, generation of reactive oxygen species, or intrace cellular introduction of oxidised glutathione (GSSG)—cortisol appears to underlie the therapeutic efficacy of MR blockade in heart failure and in essential hypertension.
Renal mineralocorticoid receptors and hippocampal corticosterone-binding species have identical intrinsic steroid specificity.
  • Z. Krozowski, J. Funder
  • Biology, Medicine
    Proceedings of the National Academy of Sciences…
  • 1 October 1983
TLDR
It is suggested that hippocampal [3H]corticosterone-binding sites and renal MR may have identical intrinsic specificity for steroids, with apparent specificity differences the result of tissue-specific sequestration of naturally occurring steroids other than Aldo.
Determinants of cardiac fibrosis in experimental hypermineralocorticoid states.
TLDR
It is concluded that the myocardial fibrosis observed in response to chronic mineralocorticoid elevation and salt loading is a humorally mediated event independent of hypokalemia, hypertension, and cardiac hypertrophy.
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