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NR2C2 wt Allele

Known as: TR4, TR2R1, hTAK1 
Human NR2C2 wild-type allele is located in the vicinity of 3p25 and is approximately 106 kb in length. This allele, which encodes nuclear receptor… 
National Institutes of Health

Related topics

Related topics

15 relations
3p25Androgen Receptor Regulation PathwayBiologic DevelopmentCell Differentiation process

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
TR4 nuclear receptor promotes clear cell renal cell carcinoma (ccRCC) vasculogenic mimicry (VM) formation and metastasis via altering the miR490-3p/vimentin signals
While TR4 nuclear receptor plays key roles to promote prostate cancer progression, its roles to alter the progression of clear… 
2013
2013
Kinase-Independent Feedback of the TAK1/TAB1 Complex on BCL10 Turnover and NF-κB Activation
ABSTRACT Antigen receptors activate pathways that control cell survival, proliferation, and differentiation. Two important… 
2012
2012
Lys48-linked TAK1 polyubiquitination at lysine-72 downregulates TNFα-induced NF-κB activation via mediating TAK1 degradation.
2011
2011
Premature aging with impaired oxidative stress defense in mice lacking TR4.
Early studies suggest that TR4 nuclear receptor is a key transcriptional factor regulating various biological activities… 
2003
2003
Expression of TAK1, a mediator of TGF-beta and BMP signaling, during mouse embryonic development.
2003
2003
Disruption of TR4 Orphan Nuclear Receptor Reduces the Expression of Liver Apolipoprotein E/C-I/C-II Gene Cluster*
Apolipoprotein E (apoE) is synthesized in many tissues, and the liver is the primary site from which apoE redistributes… 
Review
2002
Review
2002
Recent advances in the TR2 and TR4 orphan receptors of the nuclear receptor superfamily
Highly Cited
1997
Highly Cited
1997
Identification of Direct Repeat 4 as a Positive Regulatory Element for the Human TR4 Orphan Receptor
While the TR4 orphan receptor (TR4) is able to repress the expression of its target genes via its interaction with the direct… 
Highly Cited
1995
Highly Cited
1995
Suppression of Gene Expression on the Simian Virus 40 Major Late Promoter by Human TR4 Orphan Receptor
The key expression of the simian virus 40 (SV40) major late promoter could be repressed by the human TR4 orphan receptor via the… 
1995
1995
The orphan receptor TAK1 acts as a repressor of RAR-, RXR- and T3R-mediated signaling pathways.
Recently, we reported the cloning and characterization of the novel orphan receptor TAK1. In this study, we analyze the… 
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