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NR1I3 gene

Known as: constitutive androstane receptor, CONSTITUTIVE ANDROSTANE RECEPTOR, BETA, CAR-BETA 
This gene is involved in both drug metabolism and bilirubin clearance.
National Institutes of Health

Related topics

Related topics

16 relations
Biologic DevelopmentCell Differentiation processCell ProliferationHomeostasis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Activation of the constitutive androstane receptor inhibits gluconeogenesis without affecting lipogenesis or fatty acid synthesis in human hepatocytes.
2013
2013
The time point of β-catenin knockout in hepatocytes determines their response to xenobiotic activation of the constitutive androstane receptor.
2013
2013
Influence of PPARA, RXRA, NR1I2 and NR1I3 gene polymorphisms on the lipid-lowering efficacy and safety of statin therapy.
OBJECTIVE The aim of the present study was investigate the association between six genetic variants in the nuclear receptor genes… 
2012
2012
Constitutive androstane receptor activation by 2,4,6-triphenyldioxane-1,3 suppresses the expression of the gluconeogenic genes.
2010
2010
Combined effect of regulatory polymorphisms on transcription of UGT1A1 as a cause of Gilbert syndrome
BackgroundGilbert syndrome is caused by defects in bilirubin UDP-glucuronosyltransferase (UGT1A1). The most common variation… 
2009
2009
Characterization of the porcine constitutive androstane receptor (CAR) and its splice variants
Porcine constitutive androstane receptor (CAR; NR1I3) was cloned and compared for homology and activity with mouse and human CAR… 
Highly Cited
2008
Highly Cited
2008
ATF5 Is a Highly Abundant Liver-Enriched Transcription Factor that Cooperates with Constitutive Androstane Receptor in the Transactivation of CYP2B6: Implications in Hepatic Stress Responses
Activating transcription factor (ATF) 5 is a member of the ATF/cAMP response element-binding protein family, which has been… 
2007
2007
Thermodynamic characterization of the interaction between CAR-RXR and SRC-1 peptide by isothermal titration calorimetry.
The constitutive androstane receptor (CAR) enhances transcription of specific target genes that regulate several metabolic… 
1991
1991
Participation of ABF-1 protein in expression of the Saccharomyces cerevisiae CAR1 gene
DNA fragments previously shown to be required for expression of the CAR1 (arginase) gene in Saccharomyces cerevisiae and to… 
Highly Cited
1990
Highly Cited
1990
A cis-acting element present in multiple genes serves as a repressor protein binding site for the yeast CAR1 gene
Induction of the arginase (CAR1) gene expression in Saccharomyces cerevisiae has previously been shown to require participation… 
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