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NPS 2390

Known as: NPS-2390, NPS2390 
National Institutes of Health

Papers overview

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2020
2020
The extracellular calcium‐sensing receptor promotes porcine egg activation via calcium/calmodulin‐dependent protein kinase II
Extracellular calcium is required for intracellular Ca2+ oscillations needed for egg activation, but the regulatory mechanism is… 
2016
2016
Tetrahydropalmatine protects rat pulmonary endothelial cells from irradiation-induced apoptosis by inhibiting oxidative stress and the calcium sensing receptor/phospholipase C-γ1 pathway
Abstract The aim of this study was to confirm the protective effect of tetrahydropalmatine (THP) against irradiation-induced rat… 
2015
2015
Transcription Factor CREB is Involved in CaSR‐mediated Cytoskeleton Gene Expression
Our previous studies illustrated that a steady increase of intracellular calcium concentration ([Ca2+]i) was important for… 
2015
2015
Effects of calcium-sensing receptors on apoptosis in rat hippocampus during hypoxia/reoxygenation through the ERK1/2 pathway.
OBJECTIVES To explore the effects of calcium-sensing receptors (CaSR) on apoptosis in rat hippocampus during hypoxia… 
2014
2014
Parathyroid hormone-related protein overexpression protects goat mammary gland epithelial cells from calcium-sensing receptor activation-induced apoptosis
Normal mammary gland epithelial cells and breast cancer cells express the calcium-sensing receptor (CaSR), which is the master… 
2013
2013
Expression of the calcium sensing receptor in human peripheral blood T lymphocyte and its contribution to cytokine secretion through MAPKs or NF-κB pathways.
2013
2013
Crucial Role of Calcium-Sensing Receptor Activation in Cardiac Injury of Diabetic Rats
Cardiac injury is a common pathological change frequently accompanied by diabetes mellitus. Recently, some evidence indicated… 
2011
2011
Pharmacological evidences for the stimulation of calcium-sensing receptors by nifedipine in gingival fibroblasts
Objective: To investigate pharmacologically whether CaSRs are involved in the Ca2+ antagonist-induced [Ca2+]i elevation in… 
2011
2011
Post-conditioning protecting rat cardiomyocytes from apoptosis via attenuating calcium-sensing receptor-induced endo(sarco)plasmic reticulum stress
Our previous studies demonstrated that caclium-sensing receptor (CaR) stimulation elicited phospholipase C (PLC)-mediated… 
2011
2011
The Calcium-Sensing Receptor Mediates Hypoxia-Induced Proliferation of Rat Pulmonary Artery Smooth Muscle Cells Through MEK 1 ⁄ ERK 1 , 2 and PI 3 K Pathways
Activation of the calcium-sensing receptor (CaSR) leads to an increase of intracellular calcium concentration and alteration of… 
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