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NPC 15437

Known as: Hexanamide, 2,6-diamino-N-((1-(1-oxotridecyl)-2-piperidinyl)methyl)-, NPC-15437 
 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Piperidines

Papers overview

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2012
2012
Capsaicin mediates apoptosis in human nasopharyngeal carcinoma NPC-TW 039 cells through mitochondrial depolarization and endoplasmic reticulum stress
Capsaicin, a pungent compound found in hot chili peppers, has been reported to have antitumor activities in many human cancer… Expand
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2011
2011
19,20-EpDPE, a bioactive CYP450 metabolite of DHA monoacyglyceride, decreases Ca²⁺ sensitivity in human pulmonary arteries.
The aim of this study was to investigate the effect of docosahexaenoic acid monoacylglyceride (MAG-DHA) on human pulmonary… Expand
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2010
2010
Mechanisms of endothelium-dependent vasodilation in male and female, young and aged offspring born growth restricted.
Numerous epidemiological studies have shown that cardiovascular dysfunction in adult life may be programmed by compromised growth… Expand
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Highly Cited
2007
Highly Cited
2007
Soluble Epoxide Hydrolase: A Novel Therapeutic Target in Stroke
The P450 eicosanoids epoxyeicosatrienoic acids (EETs) are produced in brain and perform important biological functions, including… Expand
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2006
2006
Contribution of epoxyeicosatrienoic acids to the hypoxia-induced activation of Ca2+-activated K+ channel current in cultured rat hippocampal astrocytes
Brief hypoxia differentially regulates the activities of Ca(2+)-activated K(+) channels (K(Ca)) in a variety of cell types. We… Expand
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2002
2002
Role of endothelial nitric oxide and smooth muscle potassium channels in cerebral arteriolar dilation in response to acidosis.
BACKGROUND AND PURPOSE Potassium channels or nitric oxide or both are major mediators of acidosis-induced dilation in the… Expand
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2001
2001
Epoxyeicosatrienoic acid-mediated renal vasodilation to arachidonic acid is enhanced in SHR.
We tested the hypothesis that cyclooxygenase-independent vasodilation produced by arachidonic acid (AA) is mediated by… Expand
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Highly Cited
2000
Highly Cited
2000
P-450 epoxygenase and NO synthase inhibitors reduce cerebral blood flow response to N-methyl-D-aspartate.
Epoxyeicosatrienoic acids are cerebral vasodilators produced in astrocytes by cytochrome P-450 epoxygenase activity. The P-450… Expand
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Highly Cited
2000
Highly Cited
2000
Cytochrome P450 and cyclooxygenase metabolites contribute to the endothelin-1 afferent arteriolar vasoconstrictor and calcium responses.
Arachidonic acid metabolites contribute to the endothelin-1 (ET-1)-induced decrease in renal blood flow, but the vascular sites… Expand
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Highly Cited
1999
Highly Cited
1999
Contribution of cytochrome P450 epoxygenase and hydroxylase pathways to afferent arteriolar autoregulatory responsiveness.
Previous studies have demonstrated an important role for the cytochrome P450 (CYT-P450) pathway in afferent arteriole… Expand
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