FAQ

NOS activity (molecular function)

Known as: N2-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming), nopaline dehydrogenase activity, nopaline synthase activity 
Catalysis of the reaction: N2-(D-1,3-dicarboxypropyl)-L-arginine + NADP+ + H2O = L-arginine + 2-oxoglutarate + NADPH. [EC:1.5.1.19, MetaCyc:D… (More)

Topic mentions per year

Topic mentions per year

1985-2017
010020019852017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load.
Cardiac pressure load stimulates hypertrophy, often leading to chamber dilation and dysfunction. ROS contribute to this process… (More)
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels.
BACKGROUND Although abnormal L-arginine NO signaling contributes to endothelial dysfunction in the aging cardiovascular system… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene.
The goal of this study was to interrogate the role of inducible NO synthase (iNOS) in the late phase of ischemic preconditioning… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Acylation targets emdothelial nitric-oxide synthase to plasmalemmal caveolae.
Endothelial nitric-oxide synthase (eNOS) generates the key signaling molecule nitric oxide in response to intralumenal hormonal… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
A novel mechanism of action of tetracyclines: effects on nitric oxide synthases.
Tetracyclines have recently been shown to have "chondroprotective" effects in inflammatory arthritides in animal models. Since… (More)
Is this relevant?
Highly Cited
1994
Highly Cited
1994
Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.
Cyclooxygenase (COX) converts arachidonic acid to prostaglandin H2, which is further metabolized to prostanoids. Two isoforms of… (More)
Is this relevant?
Highly Cited
1994
Highly Cited
1994
Induction of calcium-dependent nitric oxide synthases by sex hormones.
We have examined the effects of pregnancy and sex hormones on calcium-dependent and calcium-independent nitric oxide synthases… (More)
Is this relevant?
Highly Cited
1994
Highly Cited
1994
Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells.
Histochemical activity and immunoreactivity of nitric oxide synthase (NOS, EC 1.14.13.39) have been recently demonstrated in… (More)
  • figure 1
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1994
Highly Cited
1994
Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation.
Nitric oxide (NO) produced by murine macrophages is important in murine resistance to ectromelia virus, herpes simplex virus, and… (More)
Is this relevant?
Highly Cited
1993
Highly Cited
1993
Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.
Nitric oxide is a short-lived biologic mediator for diverse cell types. Synthesis of an inducible nitric oxide synthase (NOS) in… (More)
Is this relevant?