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Accumulation of endogenous inhibitors for nitric oxide synthesis and decreased content of L‐arginine in regenerated endothelial cells
- H. Azuma, J. Sato, H. Hamasaki, A. Sugimoto, E. Isotani, S. Obayashi
- Chemistry, Medicine
- British journal of pharmacology
- 1 July 1995
1 We examined regeneration of endothelial cells (ECs), neointima formation, decreased endothelium‐dependent relaxation (EDR) and changes in the contents of L‐arginine, NG–monomethyl‐L‐arginine… Expand
Delphinidin-3-rutinoside relaxes the bovine ciliary smooth muscle through activation of ETB receptor and NO/cGMP pathway.
Delphinidin-3-rutinoside (D3R) is the major anthocyanin component in blackcurrant (Ribes nigrum L.) fruits. We investigated the relaxation mechanism of D3R in bovine ciliary smooth muscle (CM). D3R… Expand
PHARMACOLOGICAL PROPERTIES OF N‐(3′,4′‐DIMETHOXYCINNAMOYL) ANTHRANILIC ACID (N‐5′), A NEW ANTI‐ATOPIC AGENT
1 N‐(3′,4′‐dimethoxycinnamoyl) anthranilic acid (N‐5′) exhibited a dose‐dependent, potent inhibition of the passive cutaneous anaphylaxis (PCA) mediated by homocytotropic antibodies (HTA), which was… Expand
Involvement of increased arginase activity in impaired cavernous relaxation with aging in the rabbit.
- Y. Sakai, H. Masuda, K. Kihara, E. Kurosaki, Yukinao Yamauchi, H. Azuma
- The Journal of urology
- 1 July 2004
PURPOSE Arginase shares L-arginine as a common substrate with nitric oxide (NO) synthase (NOS). We examined whether increased arginase activity is involved in impaired cavernous relaxation with aging… Expand
Different Localization of ETA and ETB Receptors in the Hyperplastic Vascular Wall
- H. Azuma, H. Hamasaki, J. Sato, E. Isotani, S. Obayashi, O. Matsubara
- Journal of cardiovascular pharmacology
- 1 May 1995
We investigated which subtypes of endothelin-1 (ET-1) receptors are involved in the pathogenesis of angioplasty-induced lesion formation in the rabbit carotid artery. Four weeks after removing… Expand
Prevention of intimal thickening after endothelial removal by a nonpeptide angiotensin II receptor antagonist, losartan
1 The present experiments were designed to investigate the role of local angiotensin II receptors in the myointimal proliferative response of the vascular wall after endothelial removal, by use of a… Expand
The effects of endothelin-1 on isolated bovine ciliary muscles.
- S. Kamikawatoko, T. Tokoro, H. Azuma, H. Hamasaki, A. Ishida
- Biology, Medicine
- Experimental eye research
- 1 November 1995
The effects of endothelin-1 on bovine ciliary muscle were investigated in vitro using muscle strips prepared in two different directions (longitudinal and circular). Fifty-two bovine ciliary muscle… Expand
Nitric oxide relaxes bovine ciliary muscle contracted by carbachol through elevation of cyclic GMP.
It is generally accepted that nitric oxide relaxes vascular smooth muscles by activating guanylyl cyclase, which in turn increases cyclic 3':5' guanosine monophosphate level. Despite the… Expand
Accelerated intimal hyperplasia and increased endogenous inhibitors for NO synthesis in rabbits with alloxan‐induced hyperglycaemia
- H. Masuda, M. Goto, S. Tamaoki, H. Azuma
- Medicine, Chemistry
- British journal of pharmacology
- 1 January 1999
We examined whether endogenous inhibitors of NO synthesis are involved in the augmentation of intimal hyperplasia in rabbits with hyperglycaemia induced by alloxan. Four weeks after the endothelial… Expand
Adrenergic innervation and receptors in the sphincter of Oddi
Abstract Using a fluorescence histochemical technique, a rich distribution of specific fluorescent nerve fibers was seen along the muscle fibers in the region of the choledocho-duodenal junction of… Expand