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NNC 11-1314

Known as: NNC-11-1314, NNC111314, phenylpropargyloxy-1,2,5-thiadiazole-quinuclidine 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

QuinuclidinesThiadiazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
QM-polarized ligand docking accurately predicts the trend in binding affinity of a series of arylmethylene quinuclidine-like derivatives at the α4β2 and α3β4 nicotinic acetylcholine receptors (nAChRs…
2013
2013
Pharmacological properties and predicted binding mode of arylmethylene quinuclidine-like derivatives at the α3β4 nicotinic acetylcholine receptor (nAChR).
2012
2012
Discovery of novel α7 nicotinic acetylcholine receptor ligands via pharmacophoric and docking studies of benzylidene anabaseine analogs.
2010
2010
Multiple species metabolism of PHA-568487, a selective alpha 7 nicotinic acetylcholine receptor agonist.
The quinuclidine PHA-0568487(1) is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the… 
Highly Cited
2008
Highly Cited
2008
Structure/reactivity studies on an alpha-lithiated benzylsilane: chemical interpretation of experimental charge density.
Modern organic synthesis (e.g., of natural products) is virtually impossible without employment of enantiomerically enriched… 
2006
2006
Synthetic studies on quinine: quinuclidine construction via a ketone enolate regio- and diastereoselective Pd-mediated allylic alkylation.
7-Hydroxy-quinine was synthesized by an asymmetric aldol reaction that establishes the C8 and C9 stereochemistry, followed by… 
2005
2005
High affinity ligands for the alpha7 nicotinic receptor that show no cross-reactivity with the 5-HT3 receptor.
2002
2002
Photoelectron spectra and electronic structure of some diastereomeric quinuclidine derivatives.
The molecular and electronic structure of three pairs of diastereomeric quinuclidine derivatives (1-6) have been investigated by… 
Review
1983
Review
1983
Further developments in research on the chemistry and pharmacology of synthetic quinuclidine derivatives.
In 1969, we published a review article ‘Relationship Between the Chemical Structure and Pharmacological Activity in a Series of… 
1980
1980
Does rigidity in structure of muscarinic agonists and antagonists reflect drug specificity?
The present work is an attempt to elucidate: (1) whether highly rigid structural analogs of acetylcholine are still capable of… 
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