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NKD2 gene

Known as: naked cuticle homolog 2, NAKED CUTICLE, DROSOPHILA, HOMOLOG OF, 2, naked cuticle-2 
 
National Institutes of Health

Papers overview

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2016
2016
Curcumin inhibits tumor epithelial-mesenchymal transition by downregulating the Wnt signaling pathway and upregulating NKD2 expression in colon cancer cells
Tumor invasion and metastasis are closely associated with epithelial-mesenchymal transition (EMT). EMT refers to epithelial cells… Expand
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2016
2016
Long noncoding RNA HULC promotes colorectal carcinoma progression through epigenetically repressing NKD2 expression.
Recently, long noncoding RNAs (lncRNAs) have been emerged as crucial regulators of human diseases and prognostic markers in… Expand
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Highly Cited
2015
Highly Cited
2015
NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma
Osteosarcoma (OS) is the most frequent pediatric malignant bone tumor that has a high propensity for metastases. Through… Expand
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2015
2015
Silencing NKD2 by promoter region hypermethylation promotes gastric cancer invasion and metastasis by up-regulating SOX18 in human gastric cancer
Naked cuticle homolog2 (NKD2) is located in chromosome 5p15.3, which is frequently loss of heterozygosity in human colorectal and… Expand
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2015
2015
Epigenetic silencing of NKD2, a major component of Wnt signaling, promotes breast cancer growth
Naked cuticle homolog 2 (NKD2) has been reported to antagonize Wnt signaling in zebrafish, mouse and mammals. The aim of this… Expand
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2012
2012
Ethanol affects differentiation-related pathways and suppresses Wnt signaling protein expression in human neural stem cells.
BACKGROUND Prenatal exposure of the fetus to ethanol (EtOH) can be teratogenic. We previously showed that EtOH alters the cell… Expand
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2010
2010
Myristoylated Naked2 Antagonizes Wnt-β-Catenin Activity by Degrading Dishevelled-1 at the Plasma Membrane*
In Drosophila, naked cuticle is an inducible antagonist of the Wnt-β-catenin pathway, likely acting at the level of Dishevelled… Expand
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2008
2008
Use of Fluorescence-activated Vesicle Sorting for Isolation of Naked2-associated, Basolaterally Targeted Exocytic Vesicles for Proteomics Analysis*S
By interacting with the cytoplasmic tail of a Golgi-processed form of transforming growth factor-α (TGFα), Naked2 coats TGF… Expand
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2007
2007
Naked2 acts as a cargo recognition and targeting protein to ensure proper delivery and fusion of TGF-alpha containing exocytic vesicles at the lower lateral membrane of polarized MDCK cells.
Transforming growth factor-alpha (TGF-alpha) is the major autocrine EGF receptor ligand in vivo. In polarized epithelial cells… Expand
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2001
2001
Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2.
  • Masuko Katoh
  • International journal of oncology
  • 2001
    • Corpus ID: 20854575
Mouse Nkd is a Dishevelled-binding protein, functioning as a negative regulator of WNT - beta-catenin - TCF signaling pathway… Expand
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