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NK 109

Known as: NK-109, NK109 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Benzophenanthridines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Antiproliferative activity of O4-benzo[c]phenanthridine alkaloids against HCT-116 and HL-60 tumor cells.
2005
2005
Identification of a drug target motif: an anti-tumor drug NK109 interacts with a PNxxxxP.
Highly Cited
2000
Highly Cited
2000
Synthesis of derivatives of NK109, 7-OH benzo[c]phenanthridine alkaloid, and evaluation of their cytotoxicities and reduction-resistant properties.
Highly Cited
1999
Highly Cited
1999
Structural considerations of NK109, an antitumor benzo[c]phenanthridine alkaloid.
The antitumor activities of a synthetic benzo[c]phenanthridine, NK109 (7-hydroxy-2, 3-methylenedioxy-5-methyl-8-methoxybenzo[c… 
Highly Cited
1999
Highly Cited
1999
Synthesis and cytotoxic activities of a new benzo[c]phenanthridine alkaloid, 7-hydroxynitidine, and some 9-oxygenated benzo[c]phenanthridine derivatives.
[formula: see text] A new benzo[c]phenanthridine alkaloid, 7-hydroxynitidine, was synthesized by a novel synthetic procedure. The… 
Highly Cited
1998
Highly Cited
1998
Revision of the structure of fagaridine based on the comparison of UV and NMR data of synthetic compounds.
Fagaridine is a quaternary benzo[c]phenanthridine alkaloid, originally isolated from Fagara xanthoxyloides in 1973. The assigned… 
1997
1997
Anti-tumour activities of a new benzo[c]phenanthridine agent, 2,3-(methylenedioxy)-5-methyl-7-hydroxy-8-methoxybenzo[c]phena nthridini um hydrogensulphate dihydrate (NK109), against several drug…
Drug resistance is one of the problems severely limiting chemotherapy in cancer patients. Thus, it is very important to develop… 
1996
1996
A Topoisomerase II Inhibitor, NK109, Induces DNA Single‐ and Double‐strand Breaks and Apoptosis
2,3‐(Methylenedioxy)‐5‐methyl‐7‐hydroxy‐8‐methoxybenzo[c]phenanthridinium hydrogensulfate di‐hydrate, called NK109, is a benzo[c… 
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