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NEK11 gene

Known as: NIMA related kinase 11, NIMA-RELATED KINASE 11, NEVER IN MITOSIS GENE A-RELATED KINASE 11 
 
National Institutes of Health

Papers overview

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2019
2019
Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs
Human NimA-related kinases (Neks) have multiple mitotic and non-mitotic functions, but few substrates are known. We… Expand
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2019
2019
NEK11 as a candidate high-penetrance melanoma susceptibility gene
Background A proportion of patients diagnosed with cutaneous melanoma reports a positive family history. Inherited variants in… Expand
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2017
2017
Molecular targets and signaling pathways regulated by nuclear translocation of syndecan-1
BackgroundThe cell-surface heparan sulfate proteoglycan syndecan-1 is important for tumor cell proliferation, migration, and cell… Expand
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2016
2016
Nek11 regulates asymmetric cell division during mouse oocyte meiotic maturation.
Nek11, a member of the never in mitosis gene A (NIMA) family, is activated in somatic cells associated with G1/S or G2/M arrest… Expand
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2015
2015
Loss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging Agents
The Nek11 kinase is a potential mediator of the DNA damage response whose expression is upregulated in early stage colorectal… Expand
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2014
2014
Downregulation of NEK11 is associated with drug resistance in ovarian cancer.
NEKs [NIMA (never in mitosis gene A)-related expressed kinase] are involved in ovarian cancer development and progression, while… Expand
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2010
2010
NEK11−Linking CHK1 and CDC25A in DNA damage checkpoint signaling
The DNA damage induced G2/M checkpoint is an important guardian of the genome that prevents cell division when DNA lesions are… Expand
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Highly Cited
2009
Highly Cited
2009
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
DNA damage-induced cell-cycle checkpoints have a critical role in maintaining genomic stability. A key target of the checkpoints… Expand
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2004
2004
Nucleolar Nek11 Is a Novel Target of Nek2A in G1/S-arrested Cells*
We previously reported that Nek11, a member of the NIMA (never-in-mitosis A) family of kinases, is activated in G1/S-arrested… Expand
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Highly Cited
2002
Highly Cited
2002
Nek11, a New Member of the NIMA Family of Kinases, Involved in DNA Replication and Genotoxic Stress Responses*
DNA replication and genotoxic stresses activate various checkpoint-associated protein kinases, and checkpoint dysfunction often… Expand
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