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NEK11 gene
Known as:
NIMA related kinase 11
, NIMA-RELATED KINASE 11
, NEVER IN MITOSIS GENE A-RELATED KINASE 11
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National Institutes of Health
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Papers overview
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2019
2019
Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs
B. van de Kooij
,
P. Creixell
,
+7 authors
M. Yaffe
bioRxiv
2019
Corpus ID: 91643786
Human NimA-related kinases (Neks) have multiple mitotic and non-mitotic functions, but few substrates are known. We…
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2019
2019
NEK11 as a candidate high-penetrance melanoma susceptibility gene
E. Christodoulou
,
R. van Doorn
,
+6 authors
N. Gruis
Journal of Medical Genetics
2019
Corpus ID: 207965598
Background A proportion of patients diagnosed with cutaneous melanoma reports a positive family history. Inherited variants in…
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2016
2016
Nek11 regulates asymmetric cell division during mouse oocyte meiotic maturation.
Lei Guo
,
Zhenbo Wang
,
+5 authors
Qing-Yuan Sun
Biochemical and Biophysical Research…
2016
Corpus ID: 11030717
2015
2015
Loss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging Agents
Sarah R. Sabir
,
N. K. Sahota
,
George D.D. Jones
,
A. Fry
PLoS ONE
2015
Corpus ID: 16375833
The Nek11 kinase is a potential mediator of the DNA damage response whose expression is upregulated in early stage colorectal…
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2014
2014
Downregulation of NEK11 is associated with drug resistance in ovarian cancer.
Xia Liu
,
Yutao Gao
,
Yi Lu
,
Jian Zhang
,
Li Li
,
F. Yin
International Journal of Oncology
2014
Corpus ID: 39326153
NEKs [NIMA (never in mitosis gene A)-related expressed kinase] are involved in ovarian cancer development and progression, while…
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Review
2012
Review
2012
Cell cycle regulation by the NEK family of protein kinases
A. Fry
,
Laura O'Regan
,
Sarah R. Sabir
,
R. Bayliss
Journal of Cell Science
2012
Corpus ID: 3673251
Summary Genetic screens for cell division cycle mutants in the filamentous fungus Aspergillus nidulans led to the discovery of…
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2010
2010
NEK11−Linking CHK1 and CDC25A in DNA damage checkpoint signaling
C. Sørensen
,
M. Melixetian
,
D. Klein
,
K. Helin
Cell Cycle
2010
Corpus ID: 35307965
The DNA damage induced G2/M checkpoint is an important guardian of the genome that prevents cell division when DNA lesions are…
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Highly Cited
2009
Highly Cited
2009
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
M. Melixetian
,
D. Klein
,
C. Sørensen
,
K. Helin
Nature Cell Biology
2009
Corpus ID: 13442817
DNA damage-induced cell-cycle checkpoints have a critical role in maintaining genomic stability. A key target of the checkpoints…
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2004
2004
Nucleolar Nek11 Is a Novel Target of Nek2A in G1/S-arrested Cells*
K. Noguchi
,
H. Fukazawa
,
Y. Murakami
,
Y. Uehara
Journal of Biological Chemistry
2004
Corpus ID: 46650195
We previously reported that Nek11, a member of the NIMA (never-in-mitosis A) family of kinases, is activated in G1/S-arrested…
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Highly Cited
2002
Highly Cited
2002
Nek11, a New Member of the NIMA Family of Kinases, Involved in DNA Replication and Genotoxic Stress Responses*
K. Noguchi
,
H. Fukazawa
,
Y. Murakami
,
Y. Uehara
Journal of Biological Chemistry
2002
Corpus ID: 25546366
DNA replication and genotoxic stresses activate various checkpoint-associated protein kinases, and checkpoint dysfunction often…
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