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NEK11 gene

Known as: NIMA related kinase 11, NIMA-RELATED KINASE 11, NEVER IN MITOSIS GENE A-RELATED KINASE 11 
National Institutes of Health

Papers overview

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2019
2019
Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs
Human NimA-related kinases (Neks) have multiple mitotic and non-mitotic functions, but few substrates are known. We… 
2019
2019
NEK11 as a candidate high-penetrance melanoma susceptibility gene
Background A proportion of patients diagnosed with cutaneous melanoma reports a positive family history. Inherited variants in… 
2017
2017
Molecular targets and signaling pathways regulated by nuclear translocation of syndecan-1
BackgroundThe cell-surface heparan sulfate proteoglycan syndecan-1 is important for tumor cell proliferation, migration, and cell… 
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2015
2015
Loss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging Agents
The Nek11 kinase is a potential mediator of the DNA damage response whose expression is upregulated in early stage colorectal… 
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2014
2014
Downregulation of NEK11 is associated with drug resistance in ovarian cancer.
NEKs [NIMA (never in mitosis gene A)-related expressed kinase] are involved in ovarian cancer development and progression, while… 
Review
2012
Review
2012
Cell cycle regulation by the NEK family of protein kinases
Summary Genetic screens for cell division cycle mutants in the filamentous fungus Aspergillus nidulans led to the discovery of… 
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2010
2010
NEK11−Linking CHK1 and CDC25A in DNA damage checkpoint signaling
The DNA damage induced G2/M checkpoint is an important guardian of the genome that prevents cell division when DNA lesions are… 
Highly Cited
2009
Highly Cited
2009
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
DNA damage-induced cell-cycle checkpoints have a critical role in maintaining genomic stability. A key target of the checkpoints… 
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2004
2004
Nucleolar Nek11 Is a Novel Target of Nek2A in G1/S-arrested Cells*
We previously reported that Nek11, a member of the NIMA (never-in-mitosis A) family of kinases, is activated in G1/S-arrested… 
Highly Cited
2002
Highly Cited
2002
Nek11, a New Member of the NIMA Family of Kinases, Involved in DNA Replication and Genotoxic Stress Responses*
DNA replication and genotoxic stresses activate various checkpoint-associated protein kinases, and checkpoint dysfunction often… 
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