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NED 19

Known as: NED-19 
National Institutes of Health

Papers overview

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Review
2020
Review
2020
Targeting Two-Pore Channels: Current Progress and Future Challenges
Highly Cited
2016
Highly Cited
2016
Structure, inhibition, and regulation of two-pore channel TPC1 from Arabidopsis thaliana
Two-pore channels (TPCs) comprise a subfamily (TPC1-3) of eukaryotic voltage- and ligand-gated cation channels that contain two… 
2015
2015
Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells*
Background: TPCs are regulated by NAADP and other factors. Results: NAADP-induced Ca2+ release from acidic stores evokes… 
Highly Cited
2014
Highly Cited
2014
VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2–dependent Ca2+ signaling
Significance The formation of new blood vessels (neoangiogenesis) accompanies tissue regeneration and healing, but is also… 
2013
2013
Regulation of autophagic flux by dynein-mediated autophagosomes trafficking in mouse coronary arterial myocytes.
2013
2013
Hypoxic pulmonary vasoconstriction in the absence of pretone: essential role for intracellular Ca2+ release
•  Hypoxic pulmonary vasoconstriction (HPV) is a mechanism by which pulmonary arteries maintain blood oxygenation during alveolar… 
Highly Cited
2013
Highly Cited
2013
Two Pore Channel 2 (TPC2) Inhibits Autophagosomal-Lysosomal Fusion by Alkalinizing Lysosomal pH
Background: The role and mechanism of NAADP, an endogenous Ca2+ mobilizing nucleotide, in autophagic regulation remain to be… 
2011
2011
NAADP mediates ATP‐induced Ca2+ signals in astrocytes
Highly Cited
2011
Highly Cited
2011
NAADP links histamine H1 receptors to secretion of von Willebrand factor in human endothelial cells.
A variety of endothelial agonist-induced responses are mediated by rises in intracellular Ca(2+), suggesting that different Ca(2… 
2009
2009
Analogues of the Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Antagonist Ned-19 Indicate Two Binding Sites on the NAADP Receptor*
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a Ca2+-releasing messenger. Biological data suggest that its receptor… 
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