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Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction.
TLDR
It is suggested that stress protein elevation, rather than the nonspecific effects of thermal or ischemic stress, may be responsible for the myocardial protection seen in this model.
Effect of aging on the ability of preconditioning to protect rat hearts from ischemia-reperfusion injury.
TLDR
The results suggest that there are defects within the IP signaling cascade of the aged heart, and any IP-like mimetics to the benefit of an aging population should be considered.
Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury.
TLDR
It is suggested for the first time that increased myocardial hsp 70i expression results in protection of the heart against ischemic injury and that the antiischemic properties of hsp70i have possible therapeutic relevance.
Protein kinase C. Its role in ischemic preconditioning in the rat.
TLDR
Chelerythrine and DOG, a specific antagonist of PKC, and 1,2-dioctanoyl-sn-glycerol, were used to determine whether preconditioning could be blocked or triggered, respectively, and I/R was significantly reduced by preconditionsing and by the PKC agonist DOG.
Remote ischaemic preconditioning reduces myocardial injury in patients undergoing cardiac surgery with cold-blood cardioplegia: a randomised controlled trial
TLDR
Remote ischaemic preconditioning induced by brief ischaemia and reperfusion of the arm reduces myocardial injury in CABG surgery patients undergoing cold-blood cardioplegia, making this non-invasive cardioprotective technique widely applicable clinically.
Apelin-13 and apelin-36 exhibit direct cardioprotective activity against ischemiareperfusion injury
TLDR
This is the first study to yield evidence that the adipocytokine, apelin, produces direct cardioprotective actions involving the RISK pathway and the MPTP.
Species variation in the coronary collateral circulation during regional myocardial ischaemia: a critical determinant of the rate of evolution and extent of myocardial infarction.
TLDR
It is concluded that a wide spectrum of collateral flow exists between various mammalian species, a fact that should be taken into account in the study of the pathophysiology and control of regional ischaemia and myocardial infarction.
A "second window of protection" or delayed preconditioning phenomenon: future horizons for myocardial protection?
TLDR
This work believes that a delayed phase of protection observed many hours after the preconditioning trigger is a feature of a multifactorial stress response in the myocardium, investigation of which is relevant to gain a broader understanding of the pathophysiology of myocardial ischaemia.
Targeting residual cardiovascular risk: raising high-density lipoprotein cholesterol levels
TLDR
Raising HDL-C in patients with aggressively lowered LDL-C provides an additional strategy for addressing the residual cardiovascular risk present in these patients groups, and should lead to further improvements in clinical outcomes in these patient groups.
Does ischemic preconditioning in the human involve protein kinase C and the ATP-dependent K+ channel? Studies of contractile function after simulated ischemia in an atrial in vitro model.
TLDR
Rec was significantly improved by preconditioning by the KATP channel opener cromakalim (CK), and by the PKC activator 1,2-dioctanoyl-sn-glycerol (DOG) compared with nonpreconditioned controls when these treatments were given before the SI insult.
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