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NCR1 protein, human

Known as: NKp46 protein, human, Natural Cytotoxicity Triggering Receptor 1, CD335 Antigen 
Natural cytotoxicity triggering receptor 1 (304 aa, ~34 kDa) is encoded by the human NCR1 gene. This protein is involved in the positive regulation… 
National Institutes of Health

Related topics

Related topics

15 relations
Cell-Mediated CytolysisImmunoglobulin DomainsIntegral Membrane ProteinsLigand Binding

Broader (1)

Natural Cytotoxicity Triggering Receptor 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Targeting Natural Killer Cell Reactivity by Employing Antibody to NKp46: Implications for Type 1 Diabetes
Natural killer (NK) cells belong to the innate lymphoid cells. Their cytotoxic activity is regulated by the delicate balance… 
Highly Cited
2012
Highly Cited
2012
NKp46 expression discriminates porcine NK cells with different functional properties
So far little is known about natural killer (NK) cells in the pig due to the lack of NK cell‐specific markers. In this study, we… 
Highly Cited
2011
Highly Cited
2011
Recognition and Killing of Human and Murine Pancreatic β Cells by the NK Receptor NKp46
Type 1 diabetes is an incurable disease that is currently treated by insulin injections or in rare cases by islet transplantation… 
Highly Cited
2010
Highly Cited
2010
The activating receptor NKp46 is essential for the development of type 1 diabetes
The mechanism of action of natural killer (NK) cells in type 1 diabetes is still unknown. Here we show that the activating… 
2009
2009
Proteasome inhibition induces apoptosis in primary human natural killer cells and suppresses NKp46-mediated cytotoxicity
Bortezomib is a synthetic small molecule inhibitor of the chymotryptic activity of the 26S proteasome. Effects of bortezomib on… 
Highly Cited
2006
Highly Cited
2006
Vimentin Expressed on Mycobacterium tuberculosis-Infected Human Monocytes Is Involved in Binding to the NKp46 Receptor1
We previously showed that human NK cells used the NKp46 receptor to lyse Mycobacterium tuberculosis H37Ra-infected monocytes. To… 
Highly Cited
2004
Highly Cited
2004
The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46.
The destruction of viral-infected and tumor cells is mediated in part via the lysis receptor of natural killer (NK) cells, NKp46… 
2004
2004
Rat NKp46 activates natural killer cell cytotoxicity and is associated with FcepsilonRIgamma and CD3zeta.
NKp46 has been identified in the human, rat, mouse, monkey, and cattle. We have generated a monoclonal antibody, WEN23, against… 
Highly Cited
2003
Highly Cited
2003
Selective cross‐talk among natural cytotoxicity receptors in human natural killer cells
The cytolytic activity of human natural killer cells is induced by several triggering cell surface receptors upon interaction… 
Highly Cited
2003
Highly Cited
2003
Crystal Structure of the Human Natural Killer (NK) Cell Activating Receptor NKp46 Reveals Structural Relationship to Other Leukocyte Receptor Complex Immunoreceptors*
Natural cytotoxicity receptors (NCR) mediate lysis of a variety of tumor and virus-infected cells by natural killer (NK) cells… 
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