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NCO 700

Known as: NCO-700 
 
National Institutes of Health

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Broader (1)

Piperazines

Papers overview

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2000
2000
Tumor apoptosis induced by epoxide-containing piperazines, a new class of anti-cancer agents
Purpose: The overall purpose of this study was to determine the potential efficacy of epoxide-containing piperazines as a new… Expand
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1999
1999
Supraphysiologic concentrations of cerulein induce apoptosis in the rat pancreatic acinar cell line AR4-2J.
Little is known as yet about the role of apoptosis in pancreatic damage. This study evaluated the effects of supraphysiologic… Expand
1998
1998
Inhibition of cathepsin B does not affect the intracellular activation of trypsinogen by cerulein hyperstimulation in isolated rat pancreatic acinar cells.
Activation of trypsinogen is thought to trigger the autodigestive process in acute pancreatitis. The lysosomal enzyme cathepsin B… Expand
1998
1998
Oxidation of defined antigens allows protein unfolding and increases both proteolytic processing and exposes peptide epitopes which are recognized by specific T cells
The participation of oxidative mechanisms in major histocompatibility complex (MHC) class II‐restricted antigen presentation was… Expand
Highly Cited
1997
Highly Cited
1997
Menadione induces both necrosis and apoptosis in rat pancreatic acinar AR4-2J cells.
This study evaluated the action of menadione on cell proliferation and integrity of the rat pancreatic acinar cell line, AR4-2J… Expand
1994
1994
A protease inhibitor, NCO-700, improves the contractile function in stunned canine myocardium.
To explore the role of calcium-dependent protease in the stunned myocardium, open-chest dogs underwent 15 min of left anterior… Expand
1991
1991
Effect of NCO-700, an inhibitor of protease, on lysosomal rupture in the ischemic myocardium.
The effect of NCO-700 (1), a protease inhibitor, on subcellular distribution of lysosomal enzymes was studied in the ischemic… Expand
1985
1985
Effect of NCO-700, an inhibitor of protease, on myocardial pH decreased by coronary occlusion in dogs.
During myocardial ischemia in dogs effects of NCO-700, a protease inhibitor on myocardial pH, were investigated. Ischemia was… Expand
1985
1985
Inhibition with NCO-700, a protease inhibitor, of degradation of cardiac myofibrillar proteins during ischemia in dogs.
NCO-700 is a newly synthesized inhibitor of both cathepsin B and calcium-activated neutral protease. We examined whether NCO-700… Expand
1982
1982
Reduction of experimentally produced acute myocardial infarction size by a new synthetic inhibitor, NCO-700, against calcium-activated neutral protease.
Calcium-activated neutral protease (CANP) might be involved in the irreversible degradation of myocardial proteins in the… Expand
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