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NCO 700

Known as: NCO-700 
National Institutes of Health

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Piperazines

Papers overview

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1999
1999
Supraphysiologic concentrations of cerulein induce apoptosis in the rat pancreatic acinar cell line AR4-2J.
Little is known as yet about the role of apoptosis in pancreatic damage. This study evaluated the effects of supraphysiologic… 
1998
1998
Inhibition of cathepsin B does not affect the intracellular activation of trypsinogen by cerulein hyperstimulation in isolated rat pancreatic acinar cells.
Activation of trypsinogen is thought to trigger the autodigestive process in acute pancreatitis. The lysosomal enzyme cathepsin B… 
1997
1997
Effects of Protease Inhibitors on Postischemic Recovery of the Heart
It is well known that activation of proteases in the lysosomes and cytosol is one of the mechanisms of ischemic injury. It might… 
1994
1994
A protease inhibitor, NCO-700, improves the contractile function in stunned canine myocardium.
To explore the role of calcium-dependent protease in the stunned myocardium, open-chest dogs underwent 15 min of left anterior… 
1992
1992
The role of calcium activated neutral protease on myocardial cell injury in hypoxia.
The aim of this study was to investigate the correlation between hypoxic myocardial cell injury and intracellular protease… 
1991
1991
Effect of NCO-700, an inhibitor of protease, on lysosomal rupture in the ischemic myocardium.
The effect of NCO-700 (1), a protease inhibitor, on subcellular distribution of lysosomal enzymes was studied in the ischemic… 
1986
1986
ANTIARRHYTHMIC EFFECTS OF POSSIBLE ANTI-ISCHEMIC DRUGS
1985
1985
Effect of NCO-700, an inhibitor of protease, on myocardial pH decreased by coronary occlusion in dogs.
During myocardial ischemia in dogs effects of NCO-700, a protease inhibitor on myocardial pH, were investigated. Ischemia was… 
1985
1985
Inhibition with NCO-700, a protease inhibitor, of degradation of cardiac myofibrillar proteins during ischemia in dogs.
1982
1982
Reduction of experimentally produced acute myocardial infarction size by a new synthetic inhibitor, NCO-700, against calcium-activated neutral protease.
Calcium-activated neutral protease (CANP) might be involved in the irreversible degradation of myocardial proteins in the… 
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